Hierarchy of parameter value application - when are the values from Individuals applied?

[PavelBal]

From my understanding, values from an Individual should overwrite the values defined in the spatial structure BBs, but this is not the case.

In the attached project, there is a module iv 0.05 mg/kg (2 min) which is a human simulation imported from PK-Sim. It comes with an individual DefaultFemale. This individual defines the parameter Organism|ArterialBlood|Volume:

This parameter is not present in the SS BB of the PK-Sim module, which is by design, because it is added from the individual.

In the extension module "HUMAN - Maternal Structur includinge fetal placenta", the parameter Organism|ArterialBlood|Volume is explicitly defined in the SS BB as a table parameter:

When creating the simulation using these two modules and the individual, the value from the Extension Module is applied. While this is probably what the user would expect, I am struggling to understand how and when exactly the values from the Individual BB are applied?

[PavelBal]

When trying to do the same for a rat simulation (iv 0.05 mg/kg (2 min)_rat has been created as a rat simulation in PK-Sim), the value from the Rat individual overwrites the table:

The difference is that in the rat individual, ArterialBlood volume is a constant parameter, but in the Human individual it is a distributed parameter. So constant parameters are applied over the values defined in any BB, while distributed parameters do not overwrite parameters defined in the BBs?

This should be unified. @msevestre @Yuri05 @rwmcintosh

[msevestre]

Where is my project? I can't fix if I can't reproduce

[msevestre]

ok so after much trying, I think it's because there is actually NO value associated with the distributed parameter

<IndividualParameter id="lKLAL3zNHUiDnaIJEg-xgg" name="Volume" distributionType="Normal" dimension="Volume" isDefault="1" displayUnit="l">
      <ContainerPath path="4" />
      <ValueOrigin source="Publication" description="ICRP, 2002. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4). https://doi.org/10.1016/0146-6453(79)90123-4" />
      <Origin bb="q8_wJ40sWUy7KQWQcwnh2A" para="EGQftjk7C0qsPby4VL3g1Q" />
      <Info min="0" flag="234" seq="1" ref="0" bb="32" group="65" />
    </IndividualParameter>
    <IndividualParameter id="xhNSlSf2A0eR7W_ATwSx0Q" name="Percentile" value="0.501221079936601" isDefault="1" displayUnit="l">
      <ContainerPath path="5" />
      <Origin bb="q8_wJ40sWUy7KQWQcwnh2A" para="VhuhNm6e5kKVGEgZM68aHQ" />
      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
    </IndividualParameter>
    <IndividualParameter id="f95K9yk0P0CNDUT47jUjPw" name="Mean" dimension="Volume" value="0.963884723" isDefault="1" displayUnit="l">
      <ContainerPath path="5" />
      <Origin bb="q8_wJ40sWUy7KQWQcwnh2A" para="RLcwl08H4UqLEJwA0bwbqQ" />
      <Info min="0" flag="34" seq="1" ref="0" bb="32" group="65" />
    </IndividualParameter>
    <IndividualParameter id="REd_Pqn_gEykadgIEXZaZQ" name="Deviation" dimension="Volume" value="0.048194236" isDefault="1" displayUnit="l">
      <ContainerPath path="5" />
      <Origin bb="q8_wJ40sWUy7KQWQcwnh2A" para="pmInkP5ciE2wekyUeqxvig" />
      <Info min="0" flag="18" seq="1" ref="0" bb="32" group="65" />
    </IndividualParameter>

The value is in the mean parameter. And even this is not sure based on the percentile

[PavelBal]

@msevestre this is fixed here https://github.com/Open-Systems-Pharmacology/OSPSuite.Core/commit/c8ee38f95b255cddce3e499793de714acbf342c6

right?

[msevestre]

Correct.