Cyp1a2 cyp2c19

[PavelBal]

Add evaluation reports for:

Ethinylestradiol Mexiletine Moclobemide Omeprazole S-Mephenytoin Tizanidine

[Yuri05]

Dead links: FILE: ./Ethinylestradiol/Ethinylestradiol-Report.md [✖] link → Status: 400 [Error: ENOENT: no such file or directory, access '/github/workspace/Ethinylestradiol/link'] { errno: -2, code: 'ENOENT', syscall: 'access', path: '/github/workspace/Ethinylestradiol/link' }

[Yuri05]

@PavelBal Seems not the latest version of the https://github.com/Open-Systems-Pharmacology/Evaluation-plan-template and/or of the https://github.com/Open-Systems-Pharmacology/Qualification-text-modules were used :( Because of that, many hyperlinks are not in lower case (what I mentioned in the Fluvoxamine PR), which produces a lot of false alarms with the XRefCheck-LinkChecker, making it hard to see the real broken links. Please convert the hyperlinks to lower case and recreate the reports.

[Yuri05]

Those links are invalid not only because of lower case, but because they have dots inside, which must be removed:

⛀    Anchor '2.1-Modeling-Strategy' is not present,
⛀  Anchor   '2.1-modeling-strategy' is not present,
⛀  Anchor   '2.2.1-In-vitro-and-physico-chemical-data' is not present,
⛀  Anchor '2.2.2-Clinical-data'   is not present,
⛀  Anchor '2.2-Data' is not   present,
⛀  Anchor '2.2-data' is not   present,
⛀  Anchor   '2.3.4-Automated-Parameter-Identification' is not present,
⛀  Anchor   '2.3-Model-Parameters-and-Assumptions' is not present,
⛀  Anchor   '2.3-model-parameters-and-assumptions' is not present,
⛀  Anchor   '3.1-Final-Input-Parameters' is not present,
⛀  Anchor   '3.1-final-input-parameters' is not present,
⛀  Anchor   '3.2-Diagnostics-Plots' is not present,
⛀  Anchor   '3.2-diagnostics-plots' is not present,
⛀  Anchor '3.3.1-model-building'   is not present,
⛀  Anchor   '3.3.1-model-verification' is not present,
⛀  Anchor   '3.3-Concentration-Time-Profiles' is not present,
⛀  Anchor   '3.3-concentration-time-profiles' is not present,

[Yuri05]

@PavelBal OK, I'm pausing the review now till the issues are fixed (which are mostly the same in all reports)

[Yuri05]

Range 3?

[PavelBal]

Range 3?

This is how it looks like in PK-Sim:

In the report, I just use "all plots from pk sim". So must be a problem of the reporting engine.

[Yuri05]

Zoom in ok?

[Yuri05]

and here a zoom-in would be better...

[PavelBal]

Zoom in ok?

Issue created.

[PavelBal]

and here a zoom-in would be better...

I would say it is a shortcoming of PK-Sim or the reporting engine. Using "plot all" in reporting engine it takes the limits from PK-Sim, but I cannot define the limits in PK-Sim simply because you cannot do it in popsims. Here how it looks like in PK-Sim:

[PavelBal]

I @Yuri05 adddressed yor comments.

[Yuri05]

I would say it is a shortcoming of PK-Sim or the reporting engine. Using "plot all" in reporting engine it takes the limits from PK-Sim, but I cannot define the limits in PK-Sim simply because you cannot do it in popsims. Here how it looks like in PK-Sim:

OK, I see. Seems the PK-Sim plotting engine is just more intelligent and zooms in automatically, so that <=0 values are then "skipped" What you could do:

• Select a zoom rectangle with the maus

  

• Export project to snapshot - then the axis limits will be exported.

You could also directly set the axis limits in the snapshot :) E.g. the original snapshot looks like this:

after zooming with the maus:

So in your case you could just extend the X-Axis settings with XMin in the snapshot - and hope, that RE interprets it properly :)

...
          },
          "XAxisSettings": {
            "Min": 72,
            "AutoRange": false
          },
...

[Yuri05]

not sure if it is possible to fix: in Ethinylestradiol-Report.pdf the first glossary page is completely empty and the glossary table starts on the next page. EDIT: it's the same in all pdf reports.

[Yuri05]

@PavelBal There are few remaining typos (s. comments). After they are fixed - I think we can merge (unless you are going to fix zoom issues etc. right now)

[PavelBal]

not sure if it is possible to fix: in Ethinylestradiol-Report.pdf the first glossary page is completely empty and the glossary table starts on the next page. EDIT: it's the same in all pdf reports.

I remember I could not make it work with table spanning over multiple pages without starting it on a new page.

[PavelBal]

@Yuri05 fixed.

[PavelBal]

@Yuri05 I re-fixed the fixed that I accidentially reverted. Also removed "Source" meta data field from all observed data.

I think this can be merged now.

[Yuri05]

@PavelBal Looks good. Merging. Please adjust the model repos and creates releases ASAP