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Open-Systems-Pharmacology / OSP-PBPK-Model-Library

Library of released PBPK substance models and evaluation reports
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Questions about how to convert metabolic parameters from literature? #71

Closed balamo98 closed 1 year ago

balamo98 commented 1 year ago

Hello, I'm new inPK-sim and i have a problem about my model. I need to build a parent-metabolite model. Now,I got my compound metabolized by CYP450. 1）But I searched the value of Vmax is 2.17 (pmol/min/pmol), and the VISEF is 1.2. 2）And in the order literature ，i got the value of Vmax is 720pmol/mg protein/min. I will use the "In vitro metabolic rate in the presence of recombinant CYPs /enzyme-Michaelis-Menten". I really don’t know how to change it to "pmol/min/pmol rec.enzyme"

Yuri05 commented 1 year ago

please post your questions in the Forum discussions