CPT Pharmacometrics Syst Pharmacol. 2018 Mar 23. doi: 10.1002/psp4.12300. [Epub ahead of print]
André Dallmann, Juri Solodenko, Ibrahim Ince, Thomas Eissing
Abstract
This tutorial presents the workflow of adapting an adult physiologically based pharmacokinetic (PBPK) model to pregnant populations using the Open Systems Pharmacology (OSP) software suite (www.open-systems-pharmacology.org). This workflow is illustrated using a previously published PBPK model for metronidazole1 that is extrapolated to pregnancy by parameterizing and extending the model structure in terms of pregnancy-induced physiological changes2 . Importantly, this workflow can be applied to other scenarios where PBPK models need to be re-parameterized or structurally modified. This article is protected by copyright. All rights reserved.
KEYWORDS:
model based drug development; personalized therapy; pharmacometrics; physiologically-based pharmacokinetics; pregnancy; systems biology; systems pharmacology
https://www.ncbi.nlm.nih.gov/pubmed/29569837
CPT Pharmacometrics Syst Pharmacol. 2018 Mar 23. doi: 10.1002/psp4.12300. [Epub ahead of print]
André Dallmann, Juri Solodenko, Ibrahim Ince, Thomas Eissing
Abstract
This tutorial presents the workflow of adapting an adult physiologically based pharmacokinetic (PBPK) model to pregnant populations using the Open Systems Pharmacology (OSP) software suite (www.open-systems-pharmacology.org). This workflow is illustrated using a previously published PBPK model for metronidazole1 that is extrapolated to pregnancy by parameterizing and extending the model structure in terms of pregnancy-induced physiological changes2 . Importantly, this workflow can be applied to other scenarios where PBPK models need to be re-parameterized or structurally modified. This article is protected by copyright. All rights reserved.
KEYWORDS:
model based drug development; personalized therapy; pharmacometrics; physiologically-based pharmacokinetics; pregnancy; systems biology; systems pharmacology
PMID: 29569837 DOI: 10.1002/psp4.12300