Objectives: To broaden the study of PBPK modeling for Portuguese-speaking professionals and students by developing a basic simple PBPK modeling tutorial using free access software.
Methods: For tutorial development, the PK-Sim® software was used.
Results: A tutorial was developed in PK-Sim, completely in Portuguese, which will enable readers to perform a PBPK analysis to provide a mechanistic approach to study and predict the pharmacokinetics of medicines based on the physiological and anatomical characteristics of a population of interest, as well as in the physical and chemical properties of a particular drug.
Conclusions: Considering the importance of health technologies and their subsequent assessment, this tutorial proves as a relevant tool, both for research and development and for clinical practice, as well as leveraging the democratization of the teaching and research of Pharmaceutical Sciences among Portuguese-speaking people.
https://ojs.jaff.org.br/ojs/index.php/jaff/article/view/649 Santos de Araújo, J. M., & Johansson Azeredo, F. JORNAL DE ASSISTÊNCIA FARMACÊUTICA E FARMACOECONOMIA, 9(4). doi: https://doi.org/10.22563/2525-7323.2024.v9.n.4.p.5-17
Abstract
Objectives: To broaden the study of PBPK modeling for Portuguese-speaking professionals and students by developing a basic simple PBPK modeling tutorial using free access software.
Methods: For tutorial development, the PK-Sim® software was used.
Results: A tutorial was developed in PK-Sim, completely in Portuguese, which will enable readers to perform a PBPK analysis to provide a mechanistic approach to study and predict the pharmacokinetics of medicines based on the physiological and anatomical characteristics of a population of interest, as well as in the physical and chemical properties of a particular drug.
Conclusions: Considering the importance of health technologies and their subsequent assessment, this tutorial proves as a relevant tool, both for research and development and for clinical practice, as well as leveraging the democratization of the teaching and research of Pharmaceutical Sciences among Portuguese-speaking people.