Open PavelBal opened 1 month ago
The created PV are based on the parameters of the molecule. By name we determine if this is an 'Expression'. We currently used this definition for Global relative expression
And of course REL_EXP.
public static readonly IReadOnlyList<string> AllGlobalRelExpParameters = new[]
{
REL_EXP_BLOOD_CELLS,
REL_EXP_PLASMA,
REL_EXP_VASCULAR_ENDOTHELIUM,
};
I can shift the names easily enough.
I'm not sure how to handle determining what parameters from a molecule are 'Expression' parameters. We are currently using a list of 4 parameter names to make the determination.
The user can select organ(s) and molecules for which to add the expression profiles. Are the values taken from an existing expression profile (if so - from which)? If not - should the values be 0 by default (seems like they are)?
If I do this for CYP3A4 and "Liver" as organ, I get the following entries:
If I filter for "Liver" in the expression profile of CYP3A4, I see the following parameters:
Relative expression in vascular endothelium
,Relative expression in plasma
, andRelative expression in blood cells
should not be thereInitial concentration
,Fraction expressed interstitial
,Fraction expressed intracellular
are missing