Core functionalities of the Open Systems Pharmacology Suite
Other
5
stars
8
forks
source link
"Extend" of Initial conditions: by default, do not extend for FcRn-complexes (e.g. "Fluvoxamine-FcRn_Complex") (== use PK-Sim knowledge). This should be managed by a check box (e.g. "Do not create for FcRn blabla..") #2355
Okay, so what we need is some kind of Container criteria for molecules that are respected when extending the IC BB.
\<Molecule>-FcRn_Complex
are present inPlasma
,Interstitial
,Endosome
and "Not in container:BloodOrgan
"FcRn
only inPlasma
,Interstitial
,Endosome
and "In Container:EndogenousIgG
"LigandEndo
only "In container:EndogenousIgG
"LigandEndo_Complex
only inPlasma
,Interstitial
,Endosome
and "In Container:EndogenousIgG
"This would also solve https://github.com/Open-Systems-Pharmacology/OSPSuite.Core/issues/2356