pop pk plot for >1 PopulationSimulationSets

[Yuri05]

In the example attached there are 2 populations sets: one with the set name "10mg" and another one with the set name "25 mg". Test06.zip

PopulationSimulationSets definition

``` popSimSet1 <- PopulationSimulationSet$new( simulationFile = file.path(pkmlDir, "Raltegravir 10 mg (lactose formulation).pkml"), populationFile = file.path(inputDir, "Raltegravir Adult Population.csv"), pathID = "Organism|Heart|Plasma|Raltegravir|Concentration", pathName = "Raltegravir Heart", pathUnit = "µg/l", pkParameters = c("C_max", "t_max"), pkParametersUnits = c("µg/l", "h"), simulationSetName = "10mg" ) popSimSet2 <- PopulationSimulationSet$new( simulationFile = file.path(pkmlDir, "Raltegravir 25 mg (lactose formulation).pkml"), populationFile = file.path(inputDir, "Raltegravir Adult Population.csv"), pathID = "Organism|Heart|Plasma|Raltegravir|Concentration", pathName = "Raltegravir Heart", pathUnit = "µg/l", pkParameters = c("C_max", "t_max"), pkParametersUnits = c("µg/l", "h"), simulationSetName = "25 mg" ) ```

In this case the expectation for pk parameters box-whisker plots is: for each combination of {PK-Parameter; Output} one plot with 2 boxes is created (one box per PopulationSimulationSet}

However there is only 1 box per plot created: But it should be something like this: (s. also Matlab-Example reports, e.g. https://github.com/Open-Systems-Pharmacology/Reporting-Engine/blob/develop/advanced_examples/03_Population_Pediatric_Raltegavir/figures/pKParameter_Appendix.docx chapter 1.5)

Seems that pk values are grouped by the population name (which in this example is the same for both PopulationSimulationSets) and not by PopulationSimulationSets

[Yuri05]

s. also https://github.com/Open-Systems-Pharmacology/OSPSuite.ReportingEngine/issues/175

[pchelle]

@Yuri05 here is the update using the new Output class

A few remarks:

• Output class does not currently handle the selection of pkParameters, I will do that in the next PR to fix issue #144 for pk parameter plots on both mean and population workflows, if that's okay.
• So, currently it is only possible to select pk parameters using the task option yParameters (in attached file). There is also an option xParameters to plot yParameters as a function of xParameters.
• As requested simulationSetName need to be unique, so you get directly an error if that's not the case while you try to initialize a workflow
• If you try pediatric or ratioComparison, you will also need one unique reference population. So, you need to define for one of the PopulationSimulationSets, the following input referencePopulation = TRUE otherwise, you'll get an error while initializing the workflow. Test06.zip

[Yuri05]

@pchelle Great!

Regarding the question:

Currently the selection of PK parameters to plot is handled that way, Let me know if you prefer this to be included in Output popWorkFlow$plotPKParameters$yParameters <- c("C_max", "t_max")

Yes, let's include PK-Parameters in the output definition!