Population plots and tables: Time profiles and Residuals

[Yuri05]

Inputs

• Output folder of the Simulate population task (with calculated simulation results)
• Output Folder for results (all results will be generated here)
• OPTIONAL Number of Cores
• Type. One of:
  • Pediatric: one population may be marked as (adult) reference
  • Parallel comparison: no population is marked as special.
  • Ratio comparison:
    • special case for analysis of one property of a population (e.g. GFR)
    • one population (e.g. "healthy") is marked as reference
    • for all other (e.g. "diseased") populations: ratios of all PK Parameters to the corresponding healthy one is calculated and plotted as Box-Whisker plot
• 1 or more populations
• List of datasets
• Settings (s. also #13):
  • Reference population ( may be empty)
    • OPTIONAL Time offset
  • display Unit for time. Default: h
  • List of time Time ranges. One plot per time range
    • Single dose: Default total range
    • For multiple dose additionally: first and last application
  • scale of y axes (lin/log/both). Default: both
  • Aggregation type for Residuals. One of {Mean, Geomean, Median}. Default: Median
  • Types of Plot. Default: all 6 plot types. For each plot: plot per pop or for all pops or both
    1. Simulated time profile: Mean, Median and 5th - 95th percentile range of the simulated time profiles (if available with data). If a reference population is defined, it is also plotted.
    2. Residuals (based on population mean or geomean or median (depending on the aggregation type) ) vs time
    3. Residuals (based on population mean or geomean or median (depending on the aggregation type) ) vs simulated output
    4. Predicted (population mean or geomean or median (depending on the aggregation type)) vs observed
    5. Histogram of residuals (For all outputs together)
    6. qq-plot of residuals (For all outputs together)

Outputs

In the output folder: all plots/tables as specified in the settings

• one subsection for each population, reference population is plotted in each population as reference
• (for all plot types except for time profiles) if specified in the settings: one section for merged plots (= all pops in one plot)
• Tables: currently NONE

[sfrechen]

Please note:

Simulated time profile: Mean, Median and 5th - 95th percentile range of the simulated time profiles (if available with data). If a reference population is defined, it is also plotted (if available with data).