search

Open-Systems-Pharmacology / OSPSuite.ReportingEngine

R implementation of the reporting engine
https://www.open-systems-pharmacology.org/OSPSuite.ReportingEngine/
Other
4 stars 5 forks source link

pediatrics - ratioplot for Cl+AUC combined in 1 #472

Open Incei opened 5 years ago

Incei commented 5 years ago

An overview ratio-plot including all study data is necessary to show overall predictability for a certain compound(s).

For pediatric qualification currently only combined ratio-plots can be made if all ratios are clearance or AUC.

We urgently need the option to be able to put all ratios (AUC and CL) under 1 ratio-plot.

@Yuri05 @sfrechen

sfrechen commented 5 years ago

Disagree.

Can be handled via preprocessing of data.

Incei commented 5 years ago

My opinion: if we want to have pred-vs-observed (from literature) automized and 1 to 1 compared to literature, i would prefer to omit pre-processing, which also needs another qc check for correct preprocessing.

Scenarios such as: converting AUC to clearance when non-linearity play a role, may lead to false interpretations of the results.

Perhaps then not urgent for now then.