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Open-Systems-Pharmacology / OSPSuite.SimModel

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Use parmeter derivatives to calculate sensitivities in PI #128

Open StephanSchaller opened 2 years ago

msevestre commented 2 years ago

Isn't it the case already?

StephanSchaller commented 2 years ago

https://computing.llnl.gov/projects/sundials/cvodes

No, I don't think so (At least Juri said not). So this is the adjoint sensitivities for use in the PI

Yuri05 commented 2 years ago

Yep, it's not done for the sensitivity calculations yet. Here we could provide the analytical solution not only for dRHS/dY (which is calculated and used also for the ODE solving without sensitivites) but also dRHS/dP - which is not done yet. https://sundials.readthedocs.io/en/latest/cvodes/Mathematics_link.html#forward-sensitivity-analysis