Transport protein in red blood cells

Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling

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Transport protein in red blood cells #1071

Closed teutonicod closed 3 years ago

teutonicod commented 5 years ago

Dear all,

I would like to create a transporter in PK-Sim which is expressed in different tissues, and red blood cells is one of them. Is there a reason why enzymatic processes and binding partners can be expressed in red blood cells (or the vascular endothelum) but transporters cannot? Since red blood cells are not available in the list of tissues where the transporters can be expressed.

Best regards,

Donato

JGWojtyniak commented 5 years ago

Dear Donato,

As far as I know, there is no specific reason why transporters cannot be expressed in red blood cells in PK-Sim. However, you can implement them in MoBi. You can find a detailed description how in the following post: https://github.com/Open-Systems-Pharmacology/Forum/issues/248

Good luck and best regards, Jan

prvmalik commented 5 years ago

Confirming @teutonicod that transporters cannot be expressed in RBC in PKSim. Same options available for influx, efflux, pgp-like. for github

msevestre commented 5 years ago

@all: The limitation is by no mean technical so I am assuming this was a request at the time to NOT offer this type of transports.

Can you describe how such transports would look if implemented in PKSim in the case of Efflux, Influx and Pgp e.g. Source and Target of transport process ?

PavelBal commented 5 years ago

Can you describe how such transports would look if implemented in PKSim in the case of Efflux, Influx and Pgp e.g. Source and Target of transport process ?

Influx - Plasma to RBC Efflux - RBC to plasma

Pgp - no idea, would not make sence in my opinion.

teutonicod commented 5 years ago

I agree with @PavelBal for the Red blood cells. I think it would be worth it also to discuss the same point for the other components of the vascular system which are not available for the transporters: I prepared a summary table below so that it could be used as base to the discussion:

RBC Influx - Plasma to RBC Efflux - RBC to plasma Pgp - Does it make sense?
Plasma--> I don't think that it make sense for the transporters
Vascular endothelium --> I think that this could be useful for macromolecules presenting an active transport across the vascular endothelium Influx - Plasma to interstitial space Efflux - Interstitial space to plasma PgP - Does it make sense?

msevestre commented 5 years ago

Let's move this issue to the PKSim repo as a feature request. Thanks everyone

Yuri05 commented 3 years ago

implemented in V10 @teutonicod Check the beta version ;)