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Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Add reference for T/2 calculation for in vitro clearance #1335

Open teutonicod opened 5 years ago

teutonicod commented 5 years ago

This entry refers to the issue https://github.com/Open-Systems-Pharmacology/Forum/issues/402 on the forum. Can you please add the reference reported in the discussion in the respective field in the software, please?

Thanks a lot!

Donato

UlrichSi commented 5 years ago

Calculating a first order rate constant from the half-life by the formula k=ln(2)/t(1/2) is quite basic reaction kinetics knowledge. See, for example: https://en.wikipedia.org/wiki/Half-life

teutonicod commented 5 years ago

@UlrichSi the reference I suggested to include is not about this transformation, but it is about the calculation of the intrinsic clearance. In this formula the T/2 (indeed often calculated with the basic formula you suggested) and the relative scaling factors for the in vitro experiment are used to calculate in vitro clearance. I think it would be important to keep trace of these formulas used in the software so that when they are applied we have a reference from literature for the calculation. Sorry if the title of the post was misleading but it was to indicate that I was referring to the entry for unspecified liver process-> in vitro T/2 clearance

UlrichSi commented 5 years ago

Ok, then I was indeed misled, Donato. I agree that it can't hurt to add helpful references.