Deletion of MoBi-imported simulation from PI possible

[AndreDlm]

Following the subsequently described workflow, PK-Sim throws the error message below. I am not sure how to interpret it and where the error is exactly located. What I did is:

• Build simulations in PK-Sim
• Export a simulation to MoBi, add a new molecule/reaction and re-import the simulation to PK-Sim
• Run a PI that includes the simulation imported from MoBi; the project file can be found here
• Delete the simulation imported from MoBi (this is possible without an error!)
• Export the project to Snapshot; the JSON file can be found here
• Re-import the Snapshot file throws the following error:

---

Information: Loading Project from snapshot file 'C:\Projects\GitHub\Erythromycin.json' Error: Object reference not set to an instance of an object.

Stack trace: at OSPSuite.Core.Domain.Services.ParameterIdentifications.IdentificationParameterFactory.<>c.b__8_0(IParameter x) at System.Linq.Enumerable.WhereSelectListIterator2.MoveNext() at System.Linq.Enumerable.<DistinctIterator>d__641.MoveNext() at System.Collections.Generic.List1..ctor(IEnumerable1 collection) at System.Linq.Enumerable.ToList[TSource](IEnumerable1 source) at OSPSuite.Core.Domain.Services.ParameterIdentifications.IdentificationParameterFactory.ensureThatDimensionsAreEqual(IEnumerable1 parameters) at OSPSuite.Core.Domain.Services.ParameterIdentifications.IdentificationParameterFactory.CreateFor(IEnumerable1 parameterSelections, ParameterIdentification parameterIdentification) at PKSim.Core.Snapshots.Mappers.IdentificationParameterMapper.<MapToModel>d__6.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Core.Snapshots.Mappers.SnapshotMapperBaseExtensions.d92.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Core.Snapshots.Mappers.ParameterIdentificationMapper.d8.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Core.Snapshots.Mappers.SnapshotMapperBaseExtensions.<MapTo>d__92.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Core.Snapshots.Mappers.ProjectMapper.<MapToModel>d__11.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Core.Snapshots.Mappers.SnapshotMapperBase2.<MapToModel>d__1.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Core.Snapshots.Services.SnapshotTask.d161.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Core.Snapshots.Services.SnapshotTask.d151.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Core.Snapshots.Services.SnapshotTask.d17.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter`1.GetResult() at PKSim.Presentation.Presenters.Snapshots.LoadProjectFromSnapshotPresenter.d4.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter1.GetResult() at PKSim.Presentation.Presenters.Snapshots.LoadFromSnapshotPresenter1.d19.MoveNext() --- End of stack trace from previous location where exception was thrown --- at System.Runtime.ExceptionServices.ExceptionDispatchInfo.Throw() at System.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccessAndDebuggerNotification(Task task) at System.Runtime.CompilerServices.TaskAwaiter.GetResult() at PKSim.Presentation.Presenters.Snapshots.LoadFromSnapshotPresenter`1.d14.MoveNext()

[Yuri05]

I think it has nothing to do with the MoBi simulations (in your project they are not part of the PI anyway). It's something in the PI itself which prevents importing it from the snapshot

[msevestre]

There is no way that the simulation can be recreated from snapshot. An error/warning should be shown when exporting to snapshot that the project won't be valid anymore

[Yuri05]

As long as MoBi simulations are part of the project, Export to snapshot stops with an error (as expected). After 2 MoBi simulations are removed from the project, it can be exported to snapshot, but reimport crashes during recreation of PI.

[msevestre]

Oh I see. Is it possible to delete a normal simulation from a project when used in a PI? (E.g would we have the same behavior when taking Mobi out if the picture?)

If yes the snapshot reimport needs to be more resilient