PK-Sim Version 9.0 stopped working

[arketkar]

Hi Today I installed the new version 9 of PK-Sim. After installation and restarting my laptop, I tried to open the program, however it just crashed down immediately with the following message. Then I uninstalled and re-installed the entire setup, however I faced the same problem. So I 'repaired' the setup through control panel. Still the same problem....its not opening at all. MoBi is opening though.

I had installed Version 8 on the same system and it was running fine. My system configuration is - Windows 7 Professional with SP1, 64 bit OS; 4 GB RAM and 1 TB hard disk.

Appreciate if you could help resolve this issue.

Thanks and regards. Anant

[Yuri05]

@arketkar Which language settings does your operating system have?

Also please export error information from you windows event log and attach it here. For this:

• Open Event Viewer (Run → eventvwr.msc).
• Right click on the Windows Logs/Application node an select Filter Current Log...
• Select Criticaland Errorevent levels and confirm with OK
• Right click on the Windows Logs/Application node again and select Save Filtered Log File As...
• save in the (default) *.evtx format
• If the prompt below appears: activate "Display information for these languages" and select "English" from the list (if the language list is empty: activate "Show all available languages first"
• Zip created .evtx file and attach it here

[arketkar]

Hi Yuri,

Thanks for your reply. Please find attached the log file. Sorry I do not know the language setting, I guess it would be English. Please let me know how to find that, in case you need that information.

Thanks. Anant

Application error log_arketkar.zip

[arketkar]

Hi Yuri,

This is what I could find about the language setting. I hope you were looking for the same.

Regards. Anant

[Yuri05]

@arketkar Can you unzip the file ApplicationSettings.xml and copy it to C:\ProgramData\Open Systems Pharmacology\PK-Sim\9.0\

(overwrite existing file if required) ApplicationSettings.zip

(the folder is hidden; if it's not shown - just enter the folder name in Windows Explorer and press ENTER)

Can you start PK-Sim now?

[arketkar]

Hi @Yuri05

Thanks for sharing that file.

I followed all the steps recommended by you. The program started, however when I kept it open for some time (without any activity) I got the same error message and it shut down. Then I restarted my laptop and opened an earlier created model (created on PK-Sim version 8) and ran one DDI simulation. The moment I clicked on the 'Export PK Analysis to csv' button, I again got the same error message and it crashed down.

Error log_24062020_arketkar.zip

I am attaching the new error log file for your reference. Appreciate if you could help to resolve this issue.

Thanks and regards. Anant

[arketkar]

Hi @Yuri05

Is it possible to have more than one versions of PK-Sim active at a time? At present I am stuck, as Version 9 is not running, and I am not able to run version 8, as it was over-written by version 9.

Regards. Anant

[PavelBal]

@arketkar You can download the portable version of PK-Sim https://github.com/Open-Systems-Pharmacology/PK-Sim/releases/tag/v8.0 Just unzip it somewhere.

[arketkar]

Hi @PavelBal Thanks for sharing that link. Just to clarify, will that run parallel to version 9 on the same system? Regards. Anant

[PavelBal]

Yes, it will not overwrite anything and you can run both versions in parallel.

[arketkar]

Thank you @PavelBal It is working in-parallel.

However my problem with PK-Sim version 9 is yet to be resolved. I am sure @Yuri05 will come up with some solution.

Regards. Anant

[msevestre]

@arketkar Going to move this issue to the PKSim repository as it seems to be related to your computer configuration

[Yuri05]

@arketkar Can you export and attach you Error event log again?

After that, please try to increase the limits for GDI/User objects as described here and restart your computer. I doubt that this will solve your problem however.

[arketkar]

Hi @Yuri05 I had attached the new Error event report earlier. Attaching that again for your ready reference (generated today).

Error log_24062020_arketkar.zip

I shall follow the additional steps recommended by you and revert. Thanks.

[arketkar]

Hi @Yuri05 I tried the steps mentioned in the link provided by you. Sorry to say but its not working. It just opened the project file, I could run one DDI simulation. The moment I clicked on export 'PK-Analysis to csv' button it again crashed down.....

@msevestre Version 8 was running fine on the same machine...however running Version 9 is becoming a problem.

Appreciate if your team can resolve this issue.

Thanks again in advance.

[msevestre]

@arketkar v9 is using a newer version of the .NET framework for example. We have no problem running the setup on win7 machines and all our tests were also successful. I am not hopeful but @Yuri05 may have other ideas :)

Just to try something .Could you download the portable version of pksim? and see if this works?

https://github.com/Open-Systems-Pharmacology/PK-Sim/releases/download/v9.0/pk-sim-portable-setup.zip

e.g. download, unzip etc..

[arketkar]

Hi @msevestre thanks for sharing the link. I tried the portable version as well. However its not working on my system...

Can you please elaborate more on the newer version of the .NET framework? Can I request my IT team to upgrade/change something in my system so that the system would become suitable to run Version 9. Is there a way I could find out the version of .NET framework and inform you?

Sorry to bother you and your team members...

[Yuri05]

@arketkar Looking at your latest EventLog - it seems that the .NET Framework 4.7.2 (which is used in OSP9) does not work properly on your computer. E.g. below you can see a crash in the WinForms FileDialog (which is one of the basic graphical elements).

WinForms FileDialog crash

``` Application: PKSim.exe Framework Version: v4.0.30319 Description: The process was terminated due to an unhandled exception. Exception Info: exception code c0000005, exception address 000007FEFD0CB3DD Stack: at System.Windows.Forms.FileDialogNative+IFileDialog.Show(IntPtr) at System.Windows.Forms.FileDialogNative+IFileDialog.Show(IntPtr) at System.Windows.Forms.FileDialog.RunDialogVista(IntPtr) at System.Windows.Forms.CommonDialog.ShowDialog(System.Windows.Forms.IWin32Window) at OSPSuite.UI.Services.DialogCreator.selectionFor(System.Windows.Forms.FileDialog, System.String, System.String, System.String, System.String, System.String) at OSPSuite.UI.Services.DialogCreator.AskForFileToSave(System.String, System.String, System.String, System.String, System.String) at PKSim.Infrastructure.Services.SimulationExportTask+d__28.MoveNext() at System.Runtime.CompilerServices.AsyncTaskMethodBuilder.Start[[System.__Canon, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089]](System.__Canon ByRef) at PKSim.Infrastructure.Services.SimulationExportTask.exportToFileAsync(System.String, System.String, System.String, System.Func`2, System.String) at PKSim.Infrastructure.Services.SimulationExportTask.ExportPKAnalysesToCSVAsync(PKSim.Core.Model.PopulationSimulation) at PKSim.Presentation.UICommands.ExportPopulationSimulationPKAnalysesCommand.b__2_0(PKSim.Core.Services.ISimulationExportTask) at OSPSuite.Core.Extensions.TaskExtensions+d__2`1[[System.__Canon, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089]].MoveNext() at System.Runtime.CompilerServices.AsyncTaskMethodBuilder.Start[[System.__Canon, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089]](System.__Canon ByRef) at OSPSuite.Core.Extensions.TaskExtensions.SecureAwait[[System.__Canon, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089]](System.__Canon, System.Func`2) at PKSim.Presentation.UICommands.ExportPopulationSimulationPKAnalysesCommand+d__2.MoveNext() at System.Runtime.CompilerServices.AsyncVoidMethodBuilder.Start[[System.__Canon, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089]](System.__Canon ByRef) at PKSim.Presentation.UICommands.ExportPopulationSimulationPKAnalysesCommand.PerformExecute() at OSPSuite.Presentation.UICommands.ObjectUICommand`1[[System.__Canon, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089]].Execute() at OSPSuite.Presentation.UICommands.UICommandExtensions.ExecuteWithinExceptionHandler(OSPSuite.Presentation.MenuAndBars.IUICommand, OSPSuite.Utility.Events.IEventPublisher, OSPSuite.Core.Services.IChangePropagator) at OSPSuite.Presentation.UICommands.UICommandExtensions.ExecuteWithinExceptionHandler(OSPSuite.Presentation.MenuAndBars.IUICommand) at OSPSuite.Presentation.MenuAndBars.MenuBarButton.Click() at OSPSuite.UI.Mappers.MenuBarButtonToBarItemMapperBase+<>c__DisplayClass1_0.b__0(System.Object, DevExpress.XtraBars.ItemClickEventArgs) at DevExpress.XtraBars.BarItem.OnClick(DevExpress.XtraBars.BarItemLink) at DevExpress.XtraBars.BarButtonItem.OnClick(DevExpress.XtraBars.BarItemLink) at DevExpress.XtraBars.BarItemLink.OnLinkClick() at DevExpress.XtraBars.BarButtonItemLink.OnLinkAction(DevExpress.XtraBars.BarLinkAction, System.Object) at DevExpress.XtraBars.ViewInfo.BarSelectionInfo.ClickLink(DevExpress.XtraBars.BarItemLink) at DevExpress.XtraBars.ViewInfo.BarSelectionInfo.UnPressLink(DevExpress.XtraBars.BarItemLink) at DevExpress.XtraBars.Ribbon.Handler.BaseRibbonHandler.OnUnPressItem(DevExpress.Utils.DXMouseEventArgs, DevExpress.XtraBars.Ribbon.ViewInfo.RibbonHitInfo) at DevExpress.XtraBars.Ribbon.Handler.BaseRibbonHandler.OnMouseUp(DevExpress.Utils.DXMouseEventArgs) at DevExpress.XtraBars.Ribbon.Handler.RibbonHandler.OnMouseUp(DevExpress.Utils.DXMouseEventArgs) at DevExpress.XtraBars.Ribbon.RibbonControl.OnMouseUp(System.Windows.Forms.MouseEventArgs) at System.Windows.Forms.Control.WmMouseUp(System.Windows.Forms.Message ByRef, System.Windows.Forms.MouseButtons, Int32) at System.Windows.Forms.Control.WndProc(System.Windows.Forms.Message ByRef) at DevExpress.Utils.Controls.ControlBase.WndProc(System.Windows.Forms.Message ByRef) at DevExpress.XtraBars.Ribbon.RibbonControl.WndProc(System.Windows.Forms.Message ByRef) at System.Windows.Forms.NativeWindow.Callback(IntPtr, Int32, IntPtr, IntPtr) at DevExpress.Utils.Drawing.Helpers.NativeMethods+UnsafeNativeMethods.DefSubclassProc(IntPtr, IntPtr, IntPtr, IntPtr) at DevExpress.Utils.Drawing.Helpers.NativeMethods+UnsafeNativeMethods.DefSubclassProc(IntPtr, IntPtr, IntPtr, IntPtr) at DevExpress.Utils.Drawing.Helpers.Win32SubclasserFactory+Win32Subclasser.SubClassProcInner(IntPtr, IntPtr, IntPtr, IntPtr, IntPtr, IntPtr) at System.Windows.Forms.UnsafeNativeMethods.DispatchMessageW(MSG ByRef) at System.Windows.Forms.UnsafeNativeMethods.DispatchMessageW(MSG ByRef) at System.Windows.Forms.Application+ComponentManager.System.Windows.Forms.UnsafeNativeMethods.IMsoComponentManager.FPushMessageLoop(IntPtr, Int32, Int32) at System.Windows.Forms.Application+ThreadContext.RunMessageLoopInner(Int32, System.Windows.Forms.ApplicationContext) at System.Windows.Forms.Application+ThreadContext.RunMessageLoop(Int32, System.Windows.Forms.ApplicationContext) at Microsoft.VisualBasic.ApplicationServices.WindowsFormsApplicationBase.OnRun() at PKSim.UI.BootStrapping.PKSimApplication.OnRun() at Microsoft.VisualBasic.ApplicationServices.WindowsFormsApplicationBase.DoApplicationModel() at Microsoft.VisualBasic.ApplicationServices.WindowsFormsApplicationBase.Run(System.String[]) at PKSim.Program.Main(System.String[]) ```

Nothing we can really do here. Check your computer for problems (outdated drivers, missing system updates, etc.). If nothing helps - try to figure out with your IT-people what causes the problem.

[arketkar]

Hi @Yuri05 Thanks for informing about the .NET framework version 7.4.2. I installed that on my system along with the latest version 7.8, and confirmed that its functional. Then again installed PK-Sim version 9. It is was running fine, till I clicked on the 'PK-Analysis to csv' button. Why this particular function is causing a problem? Otherwise it was running fine. Why repeatedly it is crashing with Export to csv function?

In addition to that what I noticed that in the portable version 9, I could see the button for Export PK-Analysis to xlsx' file, and it worked well there. Why this option was not seen in the installed version of PK-Sim 9?

Sorry for too many questions....

Thanks again. Anant

[Yuri05]

closing due to inactivity (assuming the problem was solved in the meanwhile)