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Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Parameter "Fraction of blood for sampling" in PK-Sim #1976

Closed Christoph27 closed 2 years ago

Christoph27 commented 2 years ago

It would be good if the parameter "Fraction of blood for sampling" which is present in each organ is accessible also from PK-Sim.

(Currently needed for an evaluation plan which works currently only from snapshots generated via PK-Sim).

At the moment, there seems to be no really got location for it at the GUI. I would probably add a new category “Tissue Sampling” under the category “Physiology”. But maybe there are better suggestions?

msevestre commented 2 years ago

What do we use this parameter for? Is this some kind of placeholder for measured values?

Christoph27 commented 2 years ago

The parameter determines how much blood (as fraction of total blood in the organ) is used for the "Whole Organ"-Observer. If it is 1, the complete blood from the organ’s vascular space is taken into account for calculating the concentration in the organ (e.g. if your measured concentration is from imaging and you do not correct for blood vessels). If it is 0, the "Whole Organ"-Observer gives the same value as the „Tissue“ Observer. In samples from tissue dissection, you have some residual blood left, i.e. the parameter has a value between 0 and 1.

StephanSchaller commented 2 years ago

I agree. Needs to be accessibe in PK-Sim

msevestre commented 2 years ago

Oh this parameter is already present...lol easy

msevestre commented 2 years ago

here we go image