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Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Expose all parameters in the PI #2103

Open PavelBal opened 2 years ago

PavelBal commented 2 years ago

Have an additional "very advanced view" that exposes all model parameters to be selected for optimization.

msevestre commented 2 years ago

same remark as #2104 Almost all parameters can be varied in PI except the one where it does not make sense (e..g changing those parameters would compromise the model)

We need to understand the need for this

container_id container_type container_name parameter_name can_be_varied read_only visible can_be_varied_in_population group_name sequence build_mode building_block_type is_input is_changed_by_create_individual
146 ORGANISM Organism BMI 0 1 1 0 BODY_ANATOMY 5 LOCAL INDIVIDUAL 0 1
146 ORGANISM Organism Molecular weight (water) 0 1 1 0 CONSTANT 1 LOCAL SIMULATION 0 0
146 ORGANISM Organism Na 0 1 0 0 CONSTANT 1 LOCAL SIMULATION 0 0
146 ORGANISM Organism R*T 0 1 1 0 CONSTANT 1 LOCAL SIMULATION 0 0
146 ORGANISM Organism Volume (plasma) 0 1 1 0 VOLUME_PLASMA 1 LOCAL SIMULATION 0 0
146 ORGANISM Organism Weight 0 1 1 0 BODY_ANATOMY 2 LOCAL INDIVIDUAL 0 1
146 ORGANISM Organism Weight of blood organs 0 1 1 0 BODY_ANATOMY 2 LOCAL INDIVIDUAL 0 0
146 ORGANISM Organism Weight of tissue organs 0 1 1 0 BODY_ANATOMY 2 LOCAL INDIVIDUAL 0 0
147 ORGAN ArterialBlood Allometric scale factor 0 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
151 ORGAN EndogenousIgG igg_k_conv 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG igg_k_diff_int 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG igg_k_diff_pls 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG IgG_kdeg 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG IgG_kei 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG IgG_kep 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG IgG_kie 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG IgG_kin 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG IgG_kpe 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG krint 0 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG krpls 0 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
152 ORGAN Fat Volume fraction lipids scale factor 0 1 0 0 TISSUE_COMPOSITION 1 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Volume fraction water scale factor 0 1 0 0 TISSUE_COMPOSITION 1 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney GFR 0 1 1 0 GFR 99 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Renal aging scaling factor 0 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Volume (standard kidney) 0 1 0 0 BODY_ANATOMY 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Large intestinal transit time factor intercept 0 1 0 0 GI_TRANSIT_TIME 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Large intestinal transit time factor slope 0 1 0 0 GI_TRANSIT_TIME 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Volume (default) 0 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Volume fraction lipids scale factor 0 1 0 0 TISSUE_COMPOSITION 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Volume fraction proteins scale factor 0 1 0 0 TISSUE_COMPOSITION 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Volume fraction water scale factor 0 1 0 0 TISSUE_COMPOSITION 1 LOCAL INDIVIDUAL 0 0
165 ORGAN PortalVein Allometric scale factor 0 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Small intestinal transit time factor intercept 0 1 0 0 GI_TRANSIT_TIME 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Small intestinal transit time factor slope 0 1 0 0 GI_TRANSIT_TIME 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Volume (default) 0 1 0 0 ORGAN_VOLUMES 666 LOCAL INDIVIDUAL 0 0
171 ORGAN VenousBlood Allometric scale factor 0 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
176 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
177 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
179 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
182 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
183 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
185 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
188 COMPARTMENT Endosome Kd (FcRn, endogenous IgG) in endosomal space of container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
189 COMPARTMENT Interstitial Kd (FcRn, endogenous IgG) in endosomal space of container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
189 COMPARTMENT Interstitial pH 0 1 0 0 PHYSIOLOGY_PH_INT 77 LOCAL INDIVIDUAL 0 0
190 COMPARTMENT Plasma Kd (FcRn, endogenous IgG) in endosomal space of container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
194 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
195 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
197 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
208 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
209 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
211 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
214 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
215 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
217 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
220 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
221 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
223 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
227 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
229 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
231 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
241 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
242 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
244 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
247 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
248 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
250 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
253 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
254 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
256 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
265 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
266 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
268 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
271 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
273 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
275 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
278 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
279 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
281 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
284 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
285 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
287 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
1026 GENERAL MoleculeProperties Default Intestinal permeability (transcellular) 0 1 0 0 PERMEABILITY 1 GLOBAL SIMULATION 0 0
1026 GENERAL MoleculeProperties Mucosa permeability scale factor (transcellular) 0 1 0 0 PERMEABILITY 1 GLOBAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1306 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1306 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1316 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1316 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1331 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1331 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1347 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1347 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1357 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1357 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1369 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1369 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1382 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1382 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1406 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1406 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1415 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1415 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1426 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1426 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1441 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1441 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1454 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1454 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1465 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1465 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1476 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1476 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1678 COMPOUND DRUG base_For_KaPL_Factor 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG base_For_logD_Factor 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG base_For_P_cell_Factor 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG base_For_Pint_Factor 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG BP_AGP 0 1 0 0 COMPOUND 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG BP_ALBUMIN 0 1 0 0 COMPOUND 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG BP_UNKNOWN 0 1 0 0 COMPOUND 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Calculated specific intestinal permeability (transcellular) 0 1 0 0 PERMEABILITY 1 GLOBAL SIMULATION 0 0
1678 COMPOUND DRUG CT_ACID 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG CT_BASE 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG CT_NEUTRAL 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Has halogens 0 1 1 0 COMPOUND_MW 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is diprotic acid 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is diprotic base 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is diprotic base monoprotic acid 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is floating in lumen 0 1 0 0 COMPOUND 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is monoprotic acid 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is monoprotic base 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is monoprotic base diprotic acid 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is monoprotic base monoprotic acid 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is neutral 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is small molecule 0 1 1 0 COMPOUND 1 PROPERTY COMPOUND 1 0
1678 COMPOUND DRUG Is strong base 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is triprotic acid 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Is triprotic base 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Molecular weight 0 0 1 0 COMPOUND_MW 1 PROPERTY COMPOUND 1 0
1678 COMPOUND DRUG pKa_Acid_0 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_Acid_1 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_Acid_2 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_Acids_Count 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_Base_0 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_Base_1 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_Base_2 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_Bases_Count 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_OneAcid_0 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_OneBase_0 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_F1 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_F2 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_F3 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_K1 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_K2 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_K3 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_K4 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_K5 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_K6 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_K7 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_pH_WS_sol_K8 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_ThreeAcids_0 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_ThreeAcids_1 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_ThreeBases_0 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_ThreeBases_1 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_TwoAcids_0 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_TwoAcids_1 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_TwoBases_0 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG pKa_TwoBases_1 0 1 0 0 COMPOUND_PKA 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Solubility table 0 0 0 0 COMPOUND_SOLUBILITY 4 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Solubility_pKa_pH_Factor 0 1 0 0 COMPOUND_SOLUBILITY 1 PROPERTY COMPOUND 0 0
1678 COMPOUND DRUG Total drug mass 0 1 0 0 COMPOUND 1 PROPERTY SIMULATION 0 0
1678 COMPOUND DRUG Total oral drug mass 0 1 0 0 ORAL_APPLICATION 1 PROPERTY SIMULATION 0 0
1721 APPLICATION Dermal Application rate 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1725 APPLICATION Intravenous Application rate 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1727 APPLICATION Subcutaneous Application rate 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Cecum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Colon Ascendens 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Colon Descendens 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Colon Sigmoid 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Colon Transversum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Duodenum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Lower Ileum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Lower Jejunum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Rectum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Stomach 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Upper Ileum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate fraction Upper Jejunum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Release rate of the tablet 0 1 0 0 PROTOCOL 1 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Cecum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Colon Ascendens 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Colon Descendens 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Colon Sigmoid 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Colon Transversum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Duodenum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Lower Ileum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Lower Jejunum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Rectum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Stomach 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Upper Ileum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Suspension fraction Upper Jejunum 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_cae 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_colasc 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_coldesc 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_colsigm 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_coltrans 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_duo 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_lil 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_lje 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_rect 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_sto 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_uil 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_Location_uje 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull Tablet_tplus 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1728 APPLICATION Oral_Tablet_Weibull TabletIsActive 0 1 0 0 PROTOCOL 500 LOCAL SIMULATION 0 0
1729 GENERAL ProtocolSchemaItem InputDose 0 1 1 0 PROTOCOL 2 LOCAL PROTOCOL 1 0
1731 GENERAL ProtocolSchemaItem InputDose 0 1 1 0 PROTOCOL 2 LOCAL PROTOCOL 1 0
1732 GENERAL ProtocolSchemaItem InputDose 0 1 1 0 PROTOCOL 2 LOCAL PROTOCOL 1 0
1733 GENERAL ProtocolSchemaItem InputDose 0 1 1 0 PROTOCOL 2 LOCAL PROTOCOL 1 0
1734 GENERAL ProtocolSchemaItem InputDose 0 1 1 0 PROTOCOL 2 LOCAL PROTOCOL 1 0
1735 GENERAL ProtocolSchemaItem InputDose 0 1 1 0 PROTOCOL 2 LOCAL PROTOCOL 1 0
1757 PROCESS MetabolizationSpecific_FirstOrder CLspec/[Enzyme] interaction factor 0 1 0 0 COMPOUNDPROCESS_SIMULATION_PARAMETERS 4 LOCAL SIMULATION 0 0
1757 PROCESS MetabolizationSpecific_FirstOrder CLspec/[Enzyme]_app 0 1 0 0 COMPOUNDPROCESS_SIMULATION_PARAMETERS 4 LOCAL SIMULATION 0 0
1773 PROCESS LiverClearance CLspec/[Enzyme] 0 1 0 0 COMPOUNDPROCESS_SIMULATION_PARAMETERS 14 GLOBAL COMPOUND 0 0
1773 PROCESS LiverClearance Enzyme concentration 0 1 0 0 COMPOUNDPROCESS_SIMULATION_PARAMETERS 13 GLOBAL COMPOUND 0 0
1773 PROCESS LiverClearance Partition coefficient (water/protein) 0 1 0 0 COMPOUNDPROCESS_CALCULATION_PARAMETERS 9 GLOBAL COMPOUND 0 0
1773 PROCESS LiverClearance Vf (lipid, blood cells) 0 1 0 0 COMPOUNDPROCESS_CALCULATION_PARAMETERS 1 GLOBAL COMPOUND 0 0
1773 PROCESS LiverClearance Vf (protein,blood cells) 0 1 0 0 COMPOUNDPROCESS_CALCULATION_PARAMETERS 1 GLOBAL COMPOUND 0 0
1773 PROCESS LiverClearance Vf (water,blood cells) 0 1 0 0 COMPOUNDPROCESS_CALCULATION_PARAMETERS 1 GLOBAL COMPOUND 0 0
1875 PROCESS ActiveTransportSpecific_MM kcat interaction factor 0 1 0 0 COMPOUNDPROCESS_SIMULATION_PARAMETERS 4 LOCAL SIMULATION 0 0
1875 PROCESS ActiveTransportSpecific_MM kcat_app 0 1 0 0 COMPOUNDPROCESS_SIMULATION_PARAMETERS 4 LOCAL SIMULATION 0 0
1875 PROCESS ActiveTransportSpecific_MM Km interaction factor 0 1 0 0 COMPOUNDPROCESS_SIMULATION_PARAMETERS 4 LOCAL SIMULATION 0 0
1875 PROCESS ActiveTransportSpecific_MM Km_app 0 1 0 0 COMPOUNDPROCESS_SIMULATION_PARAMETERS 4 LOCAL SIMULATION 0 0
1888 GENERAL MOLECULE Partition coefficient (intracellular/water) 0 1 0 0 UNDEFINED 1 LOCAL SIMULATION 0 0
3953 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3954 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3956 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3972 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
3972 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
3976 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3977 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3979 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3987 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
3995 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
3995 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
3999 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4000 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4002 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4010 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4018 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4018 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4022 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4023 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4025 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4033 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4041 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4041 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4045 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4046 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4048 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4056 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4064 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4064 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4069 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4070 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4072 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4080 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4088 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4088 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4092 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4093 COMPARTMENT Interstitial FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4095 COMPARTMENT Plasma FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_F1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_F2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_F3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_K1 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_K2 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_K3 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_K4 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_K5 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_K6 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_K7 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4103 GENERAL MoleculeProperties pKa_pH_WS_cell_K8 0 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
4111 GENERAL MoleculeProperties Radius ratio (solute/large pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4111 GENERAL MoleculeProperties Radius ratio (solute/small pores) 0 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
4115 COMPARTMENT Endosome FcRn concentration in container 0 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
StephanSchaller commented 2 years ago

Hi @msevestre , what does your table above mean? If "can be varied" = 0, this parameter cannot be optimized, right? But for quite a few parameters above (except parameters such as BMI or formula-based parameters) I could imagine a use-case.

Here is an example of a useful Parameter in MoBi I cannot find in the PI in PK-Sim (and neither in you list): image

Yuri05 commented 2 years ago

99% of the parameters shown in https://github.com/Open-Systems-Pharmacology/PK-Sim/issues/2103#issuecomment-1067214856 are absolutely of no interest. They are just supporting parameters used internally by the models and cannot be understood by anybody without a lot of 🍸 🍸 🍸 Changing most of those parameters will also destroy te model integrity. There are very few parameters which could be shown as read-only and very few parameters which could be potentially enabled for editing. So I would suggest to go through the parameters table and select those few parameters, which can be either edited or just shown as read-only.

StephanSchaller commented 2 years ago

Changing most of those parameters will also destroy te model integrity

I don't get why you care so much? (and I have to disagree in parts) We just want a "very advanced view" for people with a lot of 🍸 🍸 🍸

...and what about the example above (P_cell_int_factor)?

PavelBal commented 2 years ago

I vote for exposing everything in the "very advanced view". So basically have the same acces as in mobi. This can break the model? Well, that's why it is very advanced, but this should not be a problem of the developers.

msevestre commented 2 years ago

This is the second list of parameters that were marked as CanBeVaried but are also read only. I am assuming that the CanBeVaried was set to true so that people would be able to update them in MoBi (MoBi does not use the readonly flag)

container_id container_type container_name parameter_name can_be_varied read_only visible can_be_varied_in_population group_name sequence build_mode building_block_type is_input is_changed_by_create_individual
146 ORGANISM Organism Age 1 1 1 0 BODY_ANATOMY 1 LOCAL INDIVIDUAL 0 1
146 ORGANISM Organism Estimated gestational age 1 1 0 0 BODY_ANATOMY 4 LOCAL INDIVIDUAL 0 0
146 ORGANISM Organism Gestational age 1 1 1 0 BODY_ANATOMY 1 LOCAL INDIVIDUAL 0 1
146 ORGANISM Organism Height 1 1 1 0 BODY_ANATOMY 3 LOCAL INDIVIDUAL 0 1
146 ORGANISM Organism MeanBW 1 1 0 0 BODY_ANATOMY 2 LOCAL INDIVIDUAL 0 1
146 ORGANISM Organism MeanHeight 1 1 0 0 BODY_ANATOMY 3 LOCAL INDIVIDUAL 0 1
146 ORGANISM Organism SA proportionality factor 1 1 0 0 PHYSIOLOGY 1 LOCAL INDIVIDUAL 0 0
146 ORGANISM Organism Scaling exponent for fluid recirculation flow rate 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
146 ORGANISM Organism Surface area scaling exponent 1 1 0 0 VASCULAR_PHYSIOLOGY 1 LOCAL INDIVIDUAL 0 0
146 ORGANISM Organism Surface/Volume ratio (blood cells) 1 1 0 0 TISSUE_PROPERTIES 2 LOCAL INDIVIDUAL 0 0
147 ORGAN ArterialBlood Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
147 ORGAN ArterialBlood Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 12 LOCAL INDIVIDUAL 0 0
147 ORGAN ArterialBlood Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 2 LOCAL INDIVIDUAL 0 1
148 ORGAN Bone Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 17 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 16 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
148 ORGAN Bone Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
148 ORGAN Bone Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 15 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
148 ORGAN Bone Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
148 ORGAN Bone Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 5 LOCAL INDIVIDUAL 0 0
148 ORGAN Bone Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 22 LOCAL INDIVIDUAL 0 1
149 ORGAN Brain Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 20 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 19 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
149 ORGAN Brain Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
149 ORGAN Brain Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 18 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
149 ORGAN Brain Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
149 ORGAN Brain Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 6 LOCAL INDIVIDUAL 0 0
149 ORGAN Brain Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
151 ORGAN EndogenousIgG f_membrane_int 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG f_membrane_pls 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Lymph flow rate 1 1 1 0 LYMPH_FLOW_RATES 25 LOCAL INDIVIDUAL 0 0
151 ORGAN EndogenousIgG Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Radius ratio (solute/large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Radius ratio (solute/small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
151 ORGAN EndogenousIgG Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 25 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 42 LOCAL INDIVIDUAL 0 1
152 ORGAN Fat Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 23 LOCAL INDIVIDUAL 0 1
152 ORGAN Fat Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 22 LOCAL INDIVIDUAL 0 1
152 ORGAN Fat Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
152 ORGAN Fat Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
152 ORGAN Fat Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 21 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
152 ORGAN Fat Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
152 ORGAN Fat Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 7 LOCAL INDIVIDUAL 0 0
152 ORGAN Fat Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 62 LOCAL INDIVIDUAL 0 1
155 ORGAN Gonads Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 32 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 31 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
155 ORGAN Gonads Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
155 ORGAN Gonads Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 30 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
155 ORGAN Gonads Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
155 ORGAN Gonads Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 10 LOCAL INDIVIDUAL 0 0
155 ORGAN Gonads Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 82 LOCAL INDIVIDUAL 0 1
156 ORGAN Heart Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 35 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 34 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
156 ORGAN Heart Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
156 ORGAN Heart Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 33 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
156 ORGAN Heart Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
156 ORGAN Heart Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 11 LOCAL INDIVIDUAL 0 0
156 ORGAN Heart Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Age of aging onset 1 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 1
157 ORGAN Kidney Aging half-time 1 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 1
157 ORGAN Kidney Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 102 LOCAL INDIVIDUAL 0 1
157 ORGAN Kidney Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney fGFRpremat 1 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 38 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 37 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
157 ORGAN Kidney Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
157 ORGAN Kidney Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 36 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney GFRmat 1 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 1
157 ORGAN Kidney Hill coefficient for aging GFR 1 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 1
157 ORGAN Kidney Hill coefficient for GFR 1 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 1
157 ORGAN Kidney Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Maximal decreasing rate factor 1 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 1
157 ORGAN Kidney Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
157 ORGAN Kidney Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
157 ORGAN Kidney TM50 for GFR 1 1 0 0 GFR 99 LOCAL INDIVIDUAL 0 1
157 ORGAN Kidney Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 12 LOCAL INDIVIDUAL 0 0
157 ORGAN Kidney Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 122 LOCAL INDIVIDUAL 0 1
158 ORGAN LargeIntestine Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Fluid recirculation flow rate 1 1 1 0 FLUID_RECIRCULATION_FLOW_RATES 16 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 50 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 49 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
158 ORGAN LargeIntestine Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
158 ORGAN LargeIntestine Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 48 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Large intestinal transit time factor 1 1 0 0 GI_TRANSIT_TIME 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Lymph flow rate 1 1 1 0 LYMPH_FLOW_RATES 16 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Mucosa blood flow fraction 1 1 0 0 GI_PHYSIOLOGY 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
158 ORGAN LargeIntestine Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
158 ORGAN LargeIntestine Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 16 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Volume (mucosa) 1 1 1 0 VOLUME_MUCOSA 1 LOCAL INDIVIDUAL 0 0
158 ORGAN LargeIntestine Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 142 LOCAL INDIVIDUAL 0 1
159 ORGAN Liver Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 57 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 54 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
159 ORGAN Liver Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
159 ORGAN Liver Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 51 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Microsomal protein mass/g tissue 1 1 0 0 MIC_PROTEIN_MASS_PER_TISSUE 53 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Number of cells/g tissue 1 1 0 0 NUMBER_OF_CELLS_PER_TISSUE 53 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
159 ORGAN Liver Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
159 ORGAN Liver Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 17 LOCAL INDIVIDUAL 0 0
159 ORGAN Liver Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 150 LOCAL INDIVIDUAL 0 1
160 ORGAN Lung Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 62 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 61 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
160 ORGAN Lung Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
160 ORGAN Lung Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 60 LOCAL INDIVIDUAL 0 1
160 ORGAN Lung Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
160 ORGAN Lung Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
160 ORGAN Lung Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 18 LOCAL INDIVIDUAL 0 0
160 ORGAN Lung Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 162 LOCAL INDIVIDUAL 0 1
161 ORGAN Muscle Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 65 LOCAL INDIVIDUAL 0 1
161 ORGAN Muscle Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 64 LOCAL INDIVIDUAL 0 1
161 ORGAN Muscle Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
161 ORGAN Muscle Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
161 ORGAN Muscle Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 63 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
161 ORGAN Muscle Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
161 ORGAN Muscle Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 19 LOCAL INDIVIDUAL 0 0
161 ORGAN Muscle Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 182 LOCAL INDIVIDUAL 0 1
162 ORGAN Pancreas Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 68 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 67 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
162 ORGAN Pancreas Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
162 ORGAN Pancreas Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 66 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
162 ORGAN Pancreas Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
162 ORGAN Pancreas Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 20 LOCAL INDIVIDUAL 0 0
162 ORGAN Pancreas Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
165 ORGAN PortalVein Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 190 LOCAL INDIVIDUAL 0 1
165 ORGAN PortalVein Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
165 ORGAN PortalVein Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 69 LOCAL INDIVIDUAL 0 0
165 ORGAN PortalVein Lymph flow rate 1 1 1 0 LYMPH_FLOW_RATES 22 LOCAL INDIVIDUAL 0 0
165 ORGAN PortalVein Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
166 ORGAN Saliva Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
166 ORGAN Saliva Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 202 LOCAL INDIVIDUAL 0 1
167 ORGAN Skin Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 72 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 71 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
167 ORGAN Skin Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
167 ORGAN Skin Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 10 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
167 ORGAN Skin Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
167 ORGAN Skin Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 23 LOCAL INDIVIDUAL 0 0
167 ORGAN Skin Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 222 LOCAL INDIVIDUAL 0 1
168 ORGAN SmallIntestine Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Fluid recirculation flow rate 1 1 1 0 FLUID_RECIRCULATION_FLOW_RATES 15 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 47 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 46 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
168 ORGAN SmallIntestine Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
168 ORGAN SmallIntestine Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 45 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Lymph flow rate 1 1 1 0 LYMPH_FLOW_RATES 15 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Mucosa blood flow fraction 1 1 0 0 GI_PHYSIOLOGY 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
168 ORGAN SmallIntestine Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
168 ORGAN SmallIntestine Small intestinal transit time factor 1 1 0 0 GI_TRANSIT_TIME 1 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 15 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Volume (mucosa) 1 1 1 0 VOLUME_MUCOSA 666 LOCAL INDIVIDUAL 0 0
168 ORGAN SmallIntestine Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 242 LOCAL INDIVIDUAL 0 1
169 ORGAN Spleen Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 75 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 74 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
169 ORGAN Spleen Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
169 ORGAN Spleen Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 73 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
169 ORGAN Spleen Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
169 ORGAN Spleen Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 24 LOCAL INDIVIDUAL 0 0
169 ORGAN Spleen Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Allometric scale factor 1 1 0 0 ALLOMETRIC_SCALE_FACTOR 1 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Blood flow rate 1 1 1 0 BLOOD_FLOW_RATES 262 LOCAL INDIVIDUAL 0 1
170 ORGAN Stomach Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Fluid recirculation flow proportionality factor 1 1 0 0 FLUID_RECIRCULATION_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 44 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 43 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
170 ORGAN Stomach Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
170 ORGAN Stomach Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 42 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Lymph flow proportionality factor 1 1 0 0 LYMPH_FLOW_RATES 1 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Organ volume mouse 1 1 0 0 ORGAN_VOLUMES 1 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
170 ORGAN Stomach Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
170 ORGAN Stomach Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 14 LOCAL INDIVIDUAL 0 0
170 ORGAN Stomach Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
171 ORGAN VenousBlood Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
171 ORGAN VenousBlood Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 9 LOCAL INDIVIDUAL 0 0
171 ORGAN VenousBlood Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
172 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 4 LOCAL SIMULATION 0 0
173 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 4 LOCAL SIMULATION 0 0
174 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 5 LOCAL SIMULATION 0 0
177 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 5 LOCAL SIMULATION 0 0
178 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 5 LOCAL SIMULATION 0 0
179 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 5 LOCAL SIMULATION 0 0
180 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 6 LOCAL SIMULATION 0 0
183 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 6 LOCAL SIMULATION 0 0
184 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 6 LOCAL SIMULATION 0 0
185 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 6 LOCAL SIMULATION 0 0
187 COMPARTMENT EndosomalClearance Volume 1 1 0 0 VOLUME_ENDOSOMAL_CLEARANCE 1 LOCAL SIMULATION 0 0
188 COMPARTMENT Endosome Specific endosomal clearance 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
188 COMPARTMENT Endosome Volume 1 1 1 0 VOLUME_ENDOSOME 25 LOCAL SIMULATION 0 0
189 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 25 LOCAL SIMULATION 0 0
190 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 25 LOCAL SIMULATION 0 0
192 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 7 LOCAL SIMULATION 0 0
195 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 7 LOCAL SIMULATION 0 0
196 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 7 LOCAL SIMULATION 0 0
197 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 7 LOCAL SIMULATION 0 0
206 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 10 LOCAL SIMULATION 0 0
209 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 10 LOCAL SIMULATION 0 0
210 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 10 LOCAL SIMULATION 0 0
211 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 10 LOCAL SIMULATION 0 0
212 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 11 LOCAL SIMULATION 0 0
215 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 11 LOCAL SIMULATION 0 0
216 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 11 LOCAL SIMULATION 0 0
217 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 11 LOCAL SIMULATION 0 0
218 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 12 LOCAL SIMULATION 0 0
221 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 12 LOCAL SIMULATION 0 0
222 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 12 LOCAL SIMULATION 0 0
223 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 12 LOCAL SIMULATION 0 0
224 COMPARTMENT Urine Volume 1 1 0 0 ORGAN_VOLUMES 666 LOCAL SIMULATION 0 0
225 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 16 LOCAL SIMULATION 0 0
229 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 16 LOCAL SIMULATION 0 0
230 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 16 LOCAL SIMULATION 0 0
231 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 16 LOCAL SIMULATION 0 0
232 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 17 LOCAL SIMULATION 0 0
236 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 17 LOCAL SIMULATION 0 0
237 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 17 LOCAL SIMULATION 0 0
238 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 17 LOCAL SIMULATION 0 0
239 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 18 LOCAL SIMULATION 0 0
242 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 18 LOCAL SIMULATION 0 0
243 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 18 LOCAL SIMULATION 0 0
244 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 18 LOCAL SIMULATION 0 0
245 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 19 LOCAL SIMULATION 0 0
248 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 19 LOCAL SIMULATION 0 0
249 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 19 LOCAL SIMULATION 0 0
250 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 19 LOCAL SIMULATION 0 0
251 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 20 LOCAL SIMULATION 0 0
254 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 20 LOCAL SIMULATION 0 0
255 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 20 LOCAL SIMULATION 0 0
256 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 20 LOCAL SIMULATION 0 0
259 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 22 LOCAL SIMULATION 0 0
260 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 22 LOCAL SIMULATION 0 0
261 COMPARTMENT Saliva Volume 1 1 0 0 ORGAN_VOLUMES 666 LOCAL SIMULATION 0 0
262 COMPARTMENT SalivaGland Volume 1 1 0 0 ORGAN_VOLUMES 666 LOCAL SIMULATION 0 0
263 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 23 LOCAL SIMULATION 0 0
266 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 23 LOCAL SIMULATION 0 0
267 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 23 LOCAL SIMULATION 0 0
268 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 23 LOCAL SIMULATION 0 0
269 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 15 LOCAL SIMULATION 0 0
273 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 15 LOCAL SIMULATION 0 0
274 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 15 LOCAL SIMULATION 0 0
275 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 15 LOCAL SIMULATION 0 0
276 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 24 LOCAL SIMULATION 0 0
279 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 24 LOCAL SIMULATION 0 0
280 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 24 LOCAL SIMULATION 0 0
281 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 24 LOCAL SIMULATION 0 0
282 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 14 LOCAL SIMULATION 0 0
285 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 14 LOCAL SIMULATION 0 0
286 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 14 LOCAL SIMULATION 0 0
287 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 14 LOCAL SIMULATION 0 0
288 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 3 LOCAL SIMULATION 0 0
289 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 3 LOCAL SIMULATION 0 0
1026 GENERAL MoleculeProperties Fraction unbound (plasma) 1 1 1 0 FRACTION_UNBOUND_PLASMA 3 GLOBAL SIMULATION 0 0
1026 GENERAL MoleculeProperties P_bc_pls_factor 1 1 0 0 PERMEABILITY 1 GLOBAL SIMULATION 0 0
1026 GENERAL MoleculeProperties P_pls_bc_factor 1 1 0 0 PERMEABILITY 1 GLOBAL SIMULATION 0 0
1096 NEIGHBORHOOD EndogenousIgG_int_EndogenousIgG_pls Surface area (plasma/interstitial) 1 1 0 0 SURFACE_AREA_PLS_INT 1 LOCAL INDIVIDUAL 0 0
1302 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1302 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1306 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1306 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1312 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1316 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1316 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1327 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1331 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1331 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1343 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1347 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1347 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1353 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1357 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1357 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1363 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1366 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1369 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1369 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1376 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1382 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1382 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1401 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1406 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1406 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1411 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1415 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1415 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1421 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1426 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1426 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1432 GENERAL MoleculeProperties SalivaPlasmaRatio 1 1 0 0 DISTRIBUTION 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1437 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1441 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1441 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1448 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1454 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1454 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1460 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1465 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1465 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties P*SA intracellular -> interstitial 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties P_cell_int_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties P_int_cell_factor 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
1471 GENERAL MoleculeProperties Partition coefficient (intracellular/water) 1 1 0 0 PARTITION_COEFFICIENT 1 LOCAL SIMULATION 0 0
1476 GENERAL MoleculeProperties Peclet number (large pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1476 GENERAL MoleculeProperties Peclet number (small pores) 1 1 0 0 TWO-PORE MODEL 1 LOCAL SIMULATION 0 0
1678 COMPOUND DRUG Effective molecular weight 1 1 1 0 COMPOUND_MW 1 PROPERTY COMPOUND 0 0
1720 FORMULATION Formulation_Tablet_Weibull Weibull parameter (alpha) 1 1 0 0 FORMULATIONS 4 LOCAL FORMULATION 0 0
1729 GENERAL ProtocolSchemaItem DrugMass 1 1 0 0 PROTOCOL 2 LOCAL SIMULATION 0 0
1731 GENERAL ProtocolSchemaItem DrugMass 1 1 0 0 PROTOCOL 2 LOCAL SIMULATION 0 0
1732 GENERAL ProtocolSchemaItem DrugMass 1 1 0 0 PROTOCOL 2 LOCAL SIMULATION 0 0
1733 GENERAL ProtocolSchemaItem Amount of water 1 1 0 0 PROTOCOL 4 LOCAL SIMULATION 0 0
1733 GENERAL ProtocolSchemaItem DrugMass 1 1 0 0 PROTOCOL 2 LOCAL SIMULATION 0 0
1734 GENERAL ProtocolSchemaItem Amount of water 1 1 0 0 PROTOCOL 4 LOCAL SIMULATION 0 0
1734 GENERAL ProtocolSchemaItem DrugMass 1 1 0 0 PROTOCOL 2 LOCAL SIMULATION 0 0
1735 GENERAL ProtocolSchemaItem DrugMass 1 1 0 0 PROTOCOL 2 LOCAL SIMULATION 0 0
3950 COMPARTMENT Duodenum Density (tissue) 1 1 0 0 DENSITY 1 LOCAL INDIVIDUAL 0 0
3950 COMPARTMENT Duodenum Fraction endosomal 1 1 0 0 FRAC_ENDOSOMAL 1 LOCAL INDIVIDUAL 0 0
3950 COMPARTMENT Duodenum Fraction interstitial 1 1 1 0 ORGAN_COMPOSITION 335 LOCAL INDIVIDUAL 0 0
3950 COMPARTMENT Duodenum Fraction intracellular 1 1 1 0 ORGAN_COMPOSITION 334 LOCAL INDIVIDUAL 0 0
3950 COMPARTMENT Duodenum Fraction of endosomal uptake from plasma 1 1 0 0 FCRN_BINDING_MODEL 0 LOCAL SIMULATION 0 0
3950 COMPARTMENT Duodenum Fraction of regional blood flow rate 1 1 0 0 GI_PHYSIOLOGY 1 LOCAL INDIVIDUAL 0 0
3950 COMPARTMENT Duodenum Fraction recycled to plasma 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3950 COMPARTMENT Duodenum Fraction vascular 1 1 1 0 ORGAN_COMPOSITION 333 LOCAL INDIVIDUAL 0 0
3950 COMPARTMENT Duodenum Rate constant for endosomal uptake 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3950 COMPARTMENT Duodenum Rate constant for recycling from endosomal space 1 1 0 0 FCRN_BINDING_MODEL 1 LOCAL SIMULATION 0 0
3950 COMPARTMENT Duodenum Volume (endothelium) 1 1 1 0 VOLUME_VASCULAR_ENDOTHELIUM 111 LOCAL INDIVIDUAL 0 0
3950 COMPARTMENT Duodenum Weight (tissue) 1 1 0 0 TISSUE_WEIGHT 1 LOCAL INDIVIDUAL 0 0
3951 COMPARTMENT BloodCells Volume 1 1 1 0 VOLUME_BLOOD_CELLS 111 LOCAL SIMULATION 0 0
3954 COMPARTMENT Interstitial Volume 1 1 1 0 VOLUME_INTERSTITIAL 111 LOCAL SIMULATION 0 0
3955 COMPARTMENT Intracellular Volume 1 1 1 0 VOLUME_INTRACELLULAR 111 LOCAL SIMULATION 0 0
3956 COMPARTMENT Plasma Volume 1 1 1 0 VOLUME_PLASMA 111 LOCAL SIMULATION 0 0
3964 GENERAL MoleculeProperties P*SA interstitial -> intracellular 1 1 0 0 PERMEABILITY 1 LOCAL SIMULATION 0 0
msevestre commented 2 years ago

I am ok to expose new parameters. All of them, even the one that do not make sense at all, does not feel right to me. The tool should no that the Avogadro constant should not be changed. We have some help parameters that if changed, will not only BREAK the model (100% sure) but also will BREAK the app in some subtle way.

Yuri05 commented 2 years ago

...and what about the example above (P_cell_int_factor)?

As I said above: there are (few) parameters where enabling editing might make sense. Like P_int<=>cell factor, Km/Vmax/CL Interaction Factor, etc. So let's identify all those parameters and enable/show them.

But we should not allow editing of parameters, which are either well known constants, or which are defined in the way where changing them makes absolutely no sense and will corrupt the model. And we should not show those tons of supporting parameters which cannot be explained to anybody (and in fact nobody cares what they do. They are purely internal artifacts.