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Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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V12: cannot create simulation with animals+Liver Plasma Clearance process #2793

Closed Yuri05 closed 1 year ago

Yuri05 commented 1 year ago

If a compound contains Liver Plasma Clearance process: simulation with this compound and a non-human individual cannot be created grafik

grafik

msevestre commented 1 year ago

Ok this happens also with molecules and expression profile when you define an ontogeny Does not make much sense but it's possible at the moment The issue is that we have in the molecule an ontogenhy parameter (as we had before). It's now a TableFormulaWithXArgument that is pointing to an ontogenh table

Question. Should it be possible to define Ontogeny for an expression profile for an species that is not human? I don't think so Then we could say

TableFormulaWithXArgument => If it points to a constant parameter, we always return the value, even if the xArgs cannot be resolved? Thougths

Yuri05 commented 1 year ago

Should it be possible to define Ontogeny for an expression profile for an species that is not human?

It should be possible only for age-dependent species - which is currently only human.

TableFormulaWithXArgument => If it points to a constant parameter, we always return the value, even if the xArgs cannot be resolved?

agree