Error loading a snapshot

[PavelBal]

Trying to load this snapshot (https://github.com/Open-Systems-Pharmacology/Fluvoxamine-Omeprazole-DDI) in the latest PK-Sim version, I get the following error:

Information: Loading Project from snapshot file 'D:\Documents\esqlabs GmbH\Research and Development - Documents\Grant Projects\OSMOSES\UseCases\V11.2\Fluvoxamine-Omeprazole-DDI.json'
Information: Loading simulation 'omeprazole 40mg po asian EM' (1/4)...
Information: Loading simulation 'omeprazole 40mg po asian PM' (2/4)...
Information: Loading simulation 'omeprazole 40mg po asian EM fluvoxamine 50mg po' (3/4)...
Warning: Simulation run failed: some variables became negative when trying to reach t=908. There are different possible reasons for this:

  - Solver tolerances are too high. Please reduce the absolute and relative tolerances by one order of magnitude (e.g. from 1E-9 to 1E-10) and restart the simulation.
  - Some variables which are allowed to be negative were defined as non-negative.
  - Model is not properly established (e.g. the kinetic should be k*[A] but was defined as k*[B] etc.)

The following variables became negative :
omeprazole 40mg po asian EM fluvoxamine 50mg po|Events|Yasui-Furukori - Fluvoxamine 25mg tablet|Fluvoxamine tablet|Application_2|Fluvoxamine
Error: Cannot load Simulation 'omeprazole 40mg po asian EM fluvoxamine 50mg po'
Information: Loading simulation 'omeprazole 40mg po asian PM fluvoxamine 50mg po' (3/4)...
Warning: Simulation run failed: some variables became negative when trying to reach t=2356. There are different possible reasons for this:

  - Solver tolerances are too high. Please reduce the absolute and relative tolerances by one order of magnitude (e.g. from 1E-9 to 1E-10) and restart the simulation.
  - Some variables which are allowed to be negative were defined as non-negative.
  - Model is not properly established (e.g. the kinetic should be k*[A] but was defined as k*[B] etc.)

The following variables became negative :
omeprazole 40mg po asian PM fluvoxamine 50mg po|Events|Yasui-Furukori - Fluvoxamine 25mg tablet|Fluvoxamine tablet|Application_4|Fluvoxamine
Error: Cannot load Simulation 'omeprazole 40mg po asian PM fluvoxamine 50mg po'
Information: Project loaded from snapshot

This did not happen before.

[msevestre]

Can you export the model structure in v11 and v12 and compare?

[PavelBal]

No, the failing simulations are not created

[msevestre]

try without running the simulation?

[msevestre]

ok the option is available .Can you try to compare the simulations please?

[PavelBal]

Not failing any more. Probably due to allowing negative values for applications.