FcRn binding reactions - use sum formulas for total amounts - Githubissues

Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling

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FcRn binding reactions - use sum formulas for total amounts #2844

Closed PavelBal closed 4 months ago

PavelBal commented 8 months ago

This way, extension of the spatial structure is not as straightforward as it should be. Simplify the formula to:

kass_FcRn * FcRn * Molecule_amount - Kd_FcRn_drug * kass_FcRn * Molecule_FcRn_amount

where Molecule_amount is the reaction parameter with the sum formula:

Tagget with:
in container: "Endosome" (resp the other containers)
not in container: EndogenousIgG

Molecule_FcRn_amount can be defined in a similar way.