When adding a pH-solubility table in the molecule building block, PK-Sim interpolates linearly between the defined values.
That's fine.
However, I have issues with the display of the pH-solubility profile. Currently, a log-scaled plot is shown which connects the observed values with a a straight line which is wrong and very misleading.
If the missing values are calculated by linear interpolation (as PK-Sim does), they will not form a straight line on a log scale, but an exponential curve.
See e.g. the example below which is taken from this discussion.
When adding a pH-solubility table in the molecule building block, PK-Sim interpolates linearly between the defined values. That's fine.
However, I have issues with the display of the pH-solubility profile. Currently, a log-scaled plot is shown which connects the observed values with a a straight line which is wrong and very misleading. If the missing values are calculated by linear interpolation (as PK-Sim does), they will not form a straight line on a log scale, but an exponential curve.
See e.g. the example below which is taken from this discussion.
Linear scale:
Log scale: