Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
Other
98 stars 49 forks source link

Unit of t1/2 in individual enzyme expression is not updated when changing unit in Expression profile #2847

Closed TWendl closed 6 months ago

TWendl commented 7 months ago

Steps to reproduce: Individual was loaded from template and opened. CYP3A4 expression profile was opened and value and unit of t1/2 were changed. -->value was updated in individual, but not unit!

Yuri05 commented 6 months ago

I can confirm that it's not just a refresh problem. When using the individual in a simulation - the simulation results are wrong. Removing the expression profile from the individual and adding it again, fixes the problem

The problem still exists in V12. It seems that only t1/2 (intestine) is affected, not other parameters. E.g. before the change: After the change:

@msevestre FYI

msevestre commented 6 months ago

I can reproduce with all paramters

msevestre commented 6 months ago

image

image

msevestre commented 6 months ago

adding and removing updates image

msevestre commented 6 months ago

updating UNIT first and then value also works

msevestre commented 6 months ago

image

image

msevestre commented 6 months ago

I think the sync is not triggered for unit change that's all