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Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Changes of gastric pH return to basal value too fast #2855

Open PavelBal opened 5 months ago

PavelBal commented 5 months ago

When simulating a meal effect, the increase in gastric pH returns back to basal value within 6 minutes:

image

It seems to be a bit too fast, e.g. here a measured profile of gastric pH after meal administration:

image

https://doi.org/10.1152/japplphysiol.00956.2001

Erik-Sjogren commented 5 months ago

This is related to https://github.com/Open-Systems-Pharmacology/PK-Sim/issues/1632

Right?

BR Erik

PavelBal commented 5 months ago

True.