Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Modeling irreversible binding in PKSim /MoBi #2864

Open zt1947 opened 7 months ago

zt1947 commented 7 months ago

I am trying to model a drug that is an alkylating agent and binds irreversibly to plasma proteins. I defined the drug in PKSim (including its metabolic degradation using endogenous enzyme expression data and defining albumin as its binding partner). I then created a simulation using the above + real patient's individual data, administration protocol and the observed TDM data. It ran smoothly and then I saved the simulation in pkml format. After loading to MoBi I encountered a problem attempting to define the drug's irreversible reaction with albumin as indicated in the enclosed file. Given that MoBi insists on a kinetic equation to describe the reaction, the parameter - "k_on" should have units of 1/(time *concentration). Such unit does not seem to be available in MoBi. As far as I understand using a wrong unit definition for this parameter created the parsing problem that prevents the completion of the defintion of the Drug - albumin reaction. I would be grateful for your assistance in resolving this to facilitate the setting up of the model I am seeking.

Kinetic equation.docx