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PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Question: Basolateral mucosa permeability (P (interstitial->intracellular) , P (intracellular- >interstitial)) not in parameter identification #2898

Open michielve opened 1 month ago

michielve commented 1 month ago

Hi,

The midazolam model in the Model library contains updated parameter values for the P (interstitial->intracellular) in both directions for the GI system.

This is labelled as the Basolateral mucosa permeability ( P (interstitial->intracellular) , P (intracellular->interstitial) ) in the model validation report section 2.3.4.

However, in the Parameter Identifications, this parameter does not exist (anymore) and can't be selected. Please advise on if this has been removed in a recent version and what parameter should be used to replace this.