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Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Add metabolizing enzyme MonoAminoOxydase A #2907

Closed abderrahmanemeslouh closed 1 month ago

abderrahmanemeslouh commented 1 month ago

Hello, I am modeling an antidepressant drug mainly metabolized by MAO-A, I am not familiar with PK-Sim, I cant find MAO-A in the metabolizing enzyme list, could you please help me to insert it. Thank you

Yuri05 commented 1 month ago

You can find expression data of MAO-A in the PK-Sim Gene Expression database. S. documentation for details: https://docs.open-systems-pharmacology.org/working-with-pk-sim/pk-sim-documentation/pk-sim-expression-profile#definition-of-new-expression-profile-in-pk-sim-r

https://docs.open-systems-pharmacology.org/working-with-pk-sim/pk-sim-documentation/pk-sim-expression-profile#editing-protein-expression-by-querying-the-expression-database

grafik

grafik

abderrahmanemeslouh commented 1 month ago

Thank you for your prompt response!

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From: Juri Solodenko @.> Sent: Wednesday, May 29, 2024 11:56:56 AM To: Open-Systems-Pharmacology/PK-Sim @.> Cc: abderrahmanemeslouh @.>; Author @.> Subject: Re: [Open-Systems-Pharmacology/PK-Sim] Add metabolizing enzyme MonoAminoOxydase A (Issue #2907)

You can find expression data of MAO-A in the PK-Sim Gene Expression database. S. documentation for details: https://docs.open-systems-pharmacology.org/working-with-pk-sim/pk-sim-documentation/pk-sim-expression-profile#definition-of-new-expression-profile-in-pk-sim-r

https://docs.open-systems-pharmacology.org/working-with-pk-sim/pk-sim-documentation/pk-sim-expression-profile#editing-protein-expression-by-querying-the-expression-database

grafik.png (view on web)https://github.com/Open-Systems-Pharmacology/PK-Sim/assets/25061876/5eb7ecf2-9abc-4176-b47b-8bc59a8ddac8

grafik.png (view on web)https://github.com/Open-Systems-Pharmacology/PK-Sim/assets/25061876/b4a45c45-641f-4dcb-af06-8dd2f06ca4db

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