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Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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fraction excreted to urine / fraction excreted to feces - calculation also for metabolites #516

Open TWendl opened 6 years ago

TWendl commented 6 years ago

This observer could be calculated for metabolites as well in the following way: f_ex = molar amount of metabolite in urine (feces) / molar amount of the administered (parent) drug. For MoBi, stoichiometry can be taken into account.

msevestre commented 6 years ago

What happened if the metabolite is also administered?

TWendl commented 6 years ago

In this (rare) case, we do not need these observers.