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Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Variability plot (or Forest plot ?) for population #579

Open msevestre opened 6 years ago

msevestre commented 6 years ago

I would like to propose the addition of new type of graph and also a new way of splitting population

Population Splitting

There are cases when we compare a population of for example 1000 individuals with clinical data coming from only 10 patients. The results can be that PK-Sim is "too precise" and it could look that it does not capture the observed data well. A way of dealing with this scenario would be to introduce a new splitting mechanism: CREATE N GROUPS WITH P INDIVIDUALS. For example, Create 4 groups with 10 individuals in each group. This option would be available when creating the population analysis. Default would be obviously take ALL individuals in 1 group or simply empty.

with this feature, comes the next proposal

Variability Plot.

It would be very helpful to be able to create a graph like so variability plot

In this example, I have split my population into 4 groups of 10 individuals and selected one PK-Parameter: AUC.

For the selected PK Parameter and for each group, the arithmetic Mean and STD (or geometric?) is calculated and displayed in the graph. The last entry corresponds to the reported observed data MEAN AUC and STD that would be an INPUT from the user. Why input: Because that cannot be calculated from the observed data or is very cumbersome to do :)

All in all, a very useful feature that would help tremendously with population analysis

StephanSchaller commented 6 years ago

I like it!

Maybe another add-on feature would be to also calculate these metrics from the observed data ;.)