Spatial structure building block outdated

[AndreDlm]

The spatial structure building block for pregnant women should be updated to reflect changes that were introduced after OSP version 6.0. For example the following parameters are missing in the spatial structure:

• Organism|Kidney|Age of aging onset
• Organism|Kidney|Aging half-time
• Organism|Kidney|GFR
• Organism|Kidney|Hill coefficient for aging GFR
• Organism|Kidney|Maximal decreasing rate factor
• Organism|Kidney|Renal aging scaling factor
• ...

Not all of these parameters are needed for the pregnancy model and it should be still possible to use the building block for the published workaround, but in some cases an error will be thrown, for example when combining the model structure it with a new pregnant individual in the R toolbox (e.g. setParameterValuesByPath()).

[mmalsmadi]

Hello

I am trying to build a pregnancy model that I started in PK-Sim, sent to MoBi Then in MoBi I did the following all the steps advised in "Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women"

Finally, when I tried to put the simulation together in MoBi, I got the following error message

When tracked the path down I found the following set of parameters

I went back to check the PkSim file for the related nonpregnant model, and these were the values

attached are the files I am working on

1983 Justins Mother IM.zip Can you please help me sort out this issue?

Thanks Mo'tasem