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Open-Systems-Pharmacology / Pregnancy-Models

Physiologically Based Pharmacokinetic Models for Pregnant Women
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Some pregnancy-specific compartments use heart formula to calculate surface area (interstitial/intracellular) #16

Open AndreDlm opened 3 years ago

AndreDlm commented 3 years ago

The compartments AmnioticFluid, Breasts, PlacentaMaternal, PlacentaFetal and Fetus use the heart formula to calculate the surface area (interstitial/intracellular). While the formula refers to the correct organ volume for surface area calculation (FIRST_NEIGHBOR|..|Volume), the numerical coefficients in the formula may be different for the pregnancy-specific organs, although difficult to tell without morphological/stereological tissue data... Anyway, this remains an assumption that should be known when using the spatial structure.

E.g. for the fetus: image

mmalsmadi commented 1 year ago

Hello

I am trying to build a pregnancy model that I started in PK-Sim, sent to MoBi Then in MoBi I did the following all the steps advised in "Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women"

Finally, when I tried to put the simulation together in MoBi, I got the following error message image

When tracked the path down I found the following set of parameters image

I went back to check the PkSim file for the related nonpregnant model, and these were the values image

attached are the files I am working on

1983 Justins Mother IM.zip Can you please help me sort out this issue?

Thanks Mo'tasem