Closed Chrizsly closed 3 years ago
@AndreDlm . Any comment on this?
The only problem that I see is that K_cell_pls
should actually be K_cell_wat
- so "Partitioning coefficient water/container" rather than "Plasma/container". Otherwise the original equation looks correct.
And since Partition coefficient (intracellular/water)
is nothing else than fu / K_cell_pls
, @Chrizsly is right.
yes I confirm that, thanks @PavelBal for commenting quickly
Ok, thanks for the clarification. Would be good if this could be updated in the next version or so. Issue resolved now.
Let's keep this one open since it's a bug;-)
Dear all,
Following the tutorial (https://doi.org/10.1002/psp4.12300) on how to extend a generic PBPK model to include pregnant females, I encountered what I believe is a wrongful implementation of the equation describing the passive diffusion of a molecule across the placental barrier. More specifically, in MoBi, after loading a PK-Sim file and adding the spatial and passive transport building blocks, the equation that is implemented looks like this:
However, the equation, like all other passive diffusion equations should look like this:![image](https://user-images.githubusercontent.com/57939062/91842734-dc8f2c80-ec54-11ea-8c46-875f5114c8bf.png)
Basically, the fraction unbound is applied to both terms and the partition coefficient is divided rather than multiplied. I would appreciate any feedback on this very much. Thanks and best,
Christian