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Open Systems Pharmacology - Live Documentation
https://docs.open-systems-pharmacology.org/
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Documenting of hidden implication when combining two PBPK models with oral administrations each #231

Open PavelBal opened 7 months ago

PavelBal commented 7 months ago

CombinedModels_DifferentResults.zip

Yuri05 commented 7 months ago

Results between which simulations were different?

PavelBal commented 7 months ago

"Bahrami 2007, 100 mg SD_new" vs "Combined_IndivBahrami", output "Fluvoxamine Peripheral Venous Blood"

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Yuri05 commented 7 months ago

The difference comes from the oral administration in the second module. Omeprazole is administered at t=0, which increases the liquid volume of the stomach and influences the fluvoxamin, which is also orally administered at t=0.

If I set amounts of water for the oral applications of omeprazole at t=0 to zero: the differences of fluvoxamine between 2 simulations are negligible (below 0.001%). So I would say we don't have a problem here @msevestre @rwmcintosh

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msevestre commented 7 months ago

nice. However, noone will ever understand the differences or the implication of mixing two modules together like this We need to document this somewhere ? @PavelBal Thoughts?

PavelBal commented 6 months ago

Hm, not even sure this is worth documenting. Actually it makes totally sense, the same would happen if you combine two administrations in PK-Sim, right?

Yuri05 commented 6 months ago

Actually it makes totally sense, the same would happen if you combine two administrations in PK-Sim, right?

yes

rwmcintosh commented 5 months ago

This can be closed right @Yuri05

Yuri05 commented 5 months ago

This can be closed right @Yuri05

Yes. The only open question remains the documentation discussion (https://github.com/Open-Systems-Pharmacology/docs/issues/231) - but we could create another issue for that.