Add Open Targets datasets for drug information

[jackapbutler]

Summary

The open targets database has multiple interesting datasets that could be incorporated into this project.

We can also enrich these datasets with additional SMILE (or other molecule metadata) using this API endpoint replacing the given ID with our CHEMBL ID's in this dataset.

Subtasks

• [x] #139 i.e.

  {"chembl_id":"CHEMBL690","event":"rhabdomyolysis","count":83,"llr":115.52155157475863,"critval":27.204180254490346,"meddraCode":"10039020"}

• [ ] #140 i.e.

  {"id":"CHEMBL253376","indications":[{"disease":"MONDO_0100096","efoName":"covid-19","references":[{"source":"ClinicalTrials","ids":["NCT04928495"]}],"maxPhaseForIndication":3},{"disease":"EFO_0001068","efoName":"malaria","references":[{"source":"ClinicalTrials","ids":["NCT04340349"]}],"maxPhaseForIndication":0}],"approvedIndications":[],"indicationCount":2}

• [ ] #141 i.e.

  {"actionType":"ANTAGONIST","mechanismOfAction":"Purinergic receptor P2Y12 antagonist","chemblIds":["CHEMBL1083385","CHEMBL1771"],"targetName":"Purinergic receptor P2Y12","targetType":"single protein","targets":["ENSG00000169313"],"references":[{"source":"DailyMed","ids":["setid=0078fb3d-3595-4ae1-a059-1d5e81c879cf"],"urls":["http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0078fb3d-3595-4ae1-a059-1d5e81c879cf"]}]}

  NOTE this dataset contains multiple CHEMBL ID's per row and needs discussions

• [ ] #142 i.e.

  {"id":"CHEMBL956","canonicalSmiles":"CC(C(=O)O)c1ccc(C(=O)c2cccs2)cc1","inchiKey":"MDKGKXOCJGEUJW-UHFFFAOYSA-N","drugType":"Small molecule","blackBoxWarning":false,"name":"SUPROFEN","yearOfFirstApproval":1985,"maximumClinicalTrialPhase":4,"hasBeenWithdrawn":true,"isApproved":true,"withdrawnNotice":{"countries":["United States"," United Kingdom"," Spain"],"classes":["Musculoskeletal toxicity"," Nephrotoxicity"],"year":1987},"tradeNames":["Profenal"],"synonyms":["NSC-303611","P-(2-thenoyl)hydratropic acid","P-2-thenoylhydratropic acid","R-25,061","R-25061","Racemic suprofen","Srendam","Sulproltin","Suprofen","Sutoprofen","TN-762","Topalgic"],"crossReferences":{"PubChem":["144204194","170465412","26748525","56463227"],"Wikipedia":["Suprofen"],"drugbank":["DB00870"],"chEBI":["9362"]},"linkedDiseases":{"rows":["EFO_0005755"],"count":1},"linkedTargets":{"rows":["ENSG00000073756","ENSG00000095303"],"count":2},"description":"Small molecule drug with a maximum clinical trial phase of IV that was first approved in 1985 and is indicated for rheumatic disease. It was withdrawn in United States,  United Kingdom and  Spain initially in 1987 due to Musculoskeletal toxicity and  Nephrotoxicity."}

  NOTE this dataset contains multiple CHEMBL ID's per row and needs discussions

[jackapbutler]

The discussion is related to how we choose to handle datasets which have lists of identifiers associated to a single property.

i.e. X,Y and Z drugs were associated with disease A