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ELN Housekeeping for synthesis of J11-1 #295

Open ConorGraham opened 9 years ago

ConorGraham commented 9 years ago

Regarding the ELN protocol on the synthesis of J11-1: http://malaria.ourexperiment.org/triazolopyrazine_se/11270/Synthesis_of_45chloro124triazolo43apyridin3ylbenzonitrile_JS_111.html

I few things need to be cleaned up on this page before it can be understood and replicated by a fellow chemist.

Firstly, I'm not sure if the first paragraph makes too much sense, "To a solution of JS 10-1 (100 mg, 0.39 mmol, crude) [This is good so far, but a comma should be here] stirred in CH2Cl2 (5.5 mL) was added Iodosobenzene diacetate (138.5 mg, 0.43 mmol)." I struggled hard with deciphering this. You have a specific amount of JS10-1, which you stirred into CH2Cl2, which is then added to iodosobenzene diacetate?

The protocol then goes on to mention TLC. Where's a photo of the labelled TLC plate? What was your solvent? What were the rf values (distance that your spot travelled, divided by the solvent front)? If I did this at home, and used water as a solvent, will it work? Will I get the same rf values?

Just a bunch of tiny stuff, that when fixed, will make your page look a lot more professional.

Conor

mattodd commented 9 years ago

@jamiescott11 - this one's for you. Conor's proof-reading some of the ELN.