OpenSourceMalaria / OSM_To_Do_List

Action Items in the Open Source Malaria Consortium
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Possible Route to Indazole Analogs #550

Open mattodd opened 6 years ago

mattodd commented 6 years ago

Not suggesting any change in focus from hitlist in #546 but I was in Nanjing last week listening to a chemist called Chengjian Zhu speaking about this nice piece of methodology:

get

and it occurred to me we could use something like this to generate some Series 4-like structures at some point. Similar to our route, though C-H in place of N and obviously one of the N's possesses a substituent. Would need proper planning, but I'm noting this here for interest, and will eventually transfer over to wiki as potential future project. I'll also see if the Nanjing group itself is interested.

MFernflower commented 6 years ago

possible_scaffolds @mattodd Are these scaffolds possible via this methodology?