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OpenSourceMalaria / Series3

Everything to do with Open Source Malaria Series 3
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OSM-Furan #2

Closed mbhebhe closed 1 year ago

mbhebhe commented 6 years ago

# Ideas on brominating OSM-Furan before ring closure image DOI: 10.1039/c6ob01657j (procedure in SI)

image https://doi.org/10.1002/chem.201504330 (procedure in SI)

image https://doi.org/10.1016/j.tet.2016.09.026 (procedure in SI)

MFernflower commented 5 years ago

@mbhebhe has this been added to the main OSMFuran googledoc?

MFernflower commented 5 years ago

@mbhebhe @mattodd Perhaps a synthchem update is warranted? I have not a clue as to what new analogues were made successfully

mbhebhe commented 5 years ago

They are still in progress

MFernflower commented 4 years ago

@mbhebhe Is there a plan for a lab update? It's been a while since I looked at S3

mbhebhe commented 4 years ago

Before the lab shut down I was in the middle if these reactions. Planning on going back into the lab soon to carry on the chemistry. Hoping these reactions will work. Any suggestions on the chemistry are welcome, especially on the Sonogashira coupling on the Cl

image

MFernflower commented 4 years ago

A total shot in the dark but there is some precedent to replacing the traditional palladium complexes with Palladium(II) 5,10,15,20-(tetra-p-tolyl)porphyrin

https://www.organic-chemistry.org/abstracts/lit6/333.shtm

A company called PorphyChem has it in stock but pricing is done by request so maybe reach out to them?

mattodd commented 1 year ago

Closing. Link installed on wiki.