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OpenSourceMalaria / Series3

Everything to do with Open Source Malaria Series 3
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More analogues of OSM-S-137 ? #9

Open MFernflower opened 5 years ago

MFernflower commented 5 years ago

OSM-S-137 appears to have moderate antimalarial activity but I feel the benzyl substituent could be a source of headache in terms of metabolic liability and general oiliness:

638491271934

MFernflower commented 5 years ago

@mbhebhe I feel if this were to be pursued the N-cyclopropylmethylpiperazinyl analogue would be a wise first choice as it's precursor is cheap: http://www.matrixscientific.com/024199.html

MFernflower commented 5 years ago

@mbhebhe I see your carrying out brominations on various ring systems - will those brominated cycles be used to make corresponding analogues of the s3 hit?

mbhebhe commented 5 years ago

Its a side project I'm doing. Not related to any s3 analogues