ChatGPT on Mycetoma and the Need for New Medicines

[mattodd]

Just for interest I asked ChatGPT to "write 200 words about mycetoma and why we need new medicines for this disease"

It replied:

"Mycetoma, also known as "Madura foot," is a chronic, debilitating, and often disfiguring disease caused by a bacterial or fungal infection that affects the skin, subcutaneous tissue, and bone. The disease is prevalent in tropical and subtropical regions, especially in rural communities with poor access to healthcare. Mycetoma typically starts with a small painless nodule that gradually grows and spreads, causing severe deformity, disability, and socioeconomic burden.

Unfortunately, mycetoma remains a neglected disease, with limited treatment options and poor outcomes. The standard treatment involves long-term antibiotic or antifungal therapy, coupled with surgical excision of the infected tissues. However, these treatments are often ineffective, toxic, and cause severe side effects, including renal and hepatic dysfunction, hearing loss, and neuropathy. Moreover, the disease frequently recurs after treatment, leading to prolonged suffering, disability, and stigma.

Therefore, there is an urgent need for new medicines and innovative therapies that can address the unmet medical needs of mycetoma patients. This requires a better understanding of the disease pathogenesis, host-pathogen interaction, and the immune response. Additionally, it demands greater investment in research and development, clinical trials, and global partnerships to accelerate the discovery and development of new drugs, vaccines, and diagnostic tools for mycetoma.

In conclusion, mycetoma is a devastating disease that affects some of the world's most vulnerable populations. Addressing this neglected disease requires a concerted effort from the scientific community, policymakers, and funding agencies to develop safe, effective, and affordable treatments that can alleviate the suffering and restore the dignity of mycetoma patients."

A good effort, built from the public writings of @wwjvdsande, Prof Fahal, DNDi and many MycetOS students!

[wwjvdsande]

Indeed a good text! I don't see anything which isn't true

[wwjvdsande]

May be we can use artificial intelligence also for in silico predicting of activities: see s41589-023-01349-8.pdf

Would our MycetOS data-set (MYOS compounds plus MMV compounds screened) be a good training data-set???? What do you think? @mattodd @OpenSourceMycetoma/corecontrib???? Has anyone any experience with this???