The first screenings in the MycetOS project included the Pathogen Box and the Stasis Box from MMV. The Malaria Box was not screened. Others screened the Malaria Box against other fungal pathogens and recently Jung et al. published their findings on screening the Malaria Box against Cryptococcus neoformans (https://msphere.asm.org/content/3/2/e00537-17). One of the compounds, compound MMV665943 (IUPAC name 4-[6-[[2-(4-aminophenyl)-3H-benzimidazol-5-yl]methyl]-1H-benzimidazol-2-yl]aniline) was found to have potent antifungal activity. The molecule was named 262 in this paper and was shown to be fungicidal against C. neoformans. Fluconazole was fungistatic. It had relatively low toxicity against mammalian cells and it was fluorescent which allows to follow its penetration into the fungal cell. Next to C. neoformans, the molecule also had activity against Lomentospora prolificans, Cryptococcus gattii and Candida albicans and fluconazole resistant isolates of these species. Due to its fluorescent and fungistatic nature, would this be an interesting molecule to look further into? Would it also be active against Madurella mycetomatis? And are there derivatives of this molecule available as well?