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OpenSourceMycetoma / Series-1-Fenarimols

Open Source Mycetoma's First Series of Molecules
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Synthetic Chemistry Summary for MycetOS Series 1 Wiki #11

Open mattodd opened 5 years ago

mattodd commented 5 years ago

@dmitrij176, who is a student here at UCL, has volunteered to tackle some to do items.

It'd be very useful to have a summary posted of the synthetic chemistry for MycetOS Series 1. The relevant wiki page is here. What we need is a scheme for the synthesis of the fenarimols. The resources we have to hand are in the paper, Hung's thesis and in Hung's ELN. We don't need something exhaustive, but just a scheme that conveys the typical conditions and typical yields for the steps. This will look very like the scheme that is in the paper, but we might want to tweak/adapt/improve. There may well need to be two schemes - one for the analogs with three Ar rings and one where there is the piperazine ring.

@dmitrij176 could you please start to generate such a scheme in Chemdraw (or something else), as well as example text that describes the synthesis? Ideally files go into the general repo area by manual upload, and text can be entered directly into the wiki. You can also drag and drop files onto this page when you post, though Chemdraw files need to be converted to zip files first, I think. If you look at other wiki pages, you will be able to find examples of how this kind of thing is done, including how to add pictures. Make a start, see how you go, and discuss below. Use "wiley" settings in Chemdraw. If you're not sure what that is, find an example Chemdraw file somewhere on OSM that looks nice, download it, delete the content and then start drawing your own structures.

One of the reasons this is useful is so that we can consult properly on whether the synthesis of fenarimols is suitable for student crowdsourcing projects.

MFernflower commented 5 years ago

Is dmitrij176 strictly doing computational and administrative work or is he also doing chemical synthesis? @mattodd I uploaded a rough sketch for the triaryl synthesis

MFernflower commented 5 years ago

@mattodd A bit unrelated but what is the status regarding @fantasy121 and this whole project - is he still on it?

fantasy121 commented 5 years ago

@MFernflower I have recently submitted my application for PhD and is about to continue with my research in June.

MFernflower commented 5 years ago

Congrats on your PhD

MFernflower commented 4 years ago

@dmitrij176 link to ELN?

dmitrij176 commented 4 years ago

@MFernflower I currently don't have an ELN.

mattodd commented 4 years ago

Working on this here and hopefully will be resolved ASAP.