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OpenSourceMycetoma / Series-1-Fenarimols

Open Source Mycetoma's First Series of Molecules
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An interesting idea #15

Closed MFernflower closed 5 years ago

MFernflower commented 5 years ago

Seeing the bicyclic system that was used in https://github.com/OpenSourceMalaria/Series4/issues/71 got me thinking:

bicyc

InChI=1S/C19H25F2N3O2/c1-2-26-17(25)24-8-6-23(7-9-24)15(14-4-3-5-22-10-14)18-11-19(12-18,13-18)16(20)21/h3-5,10,15-16H,2,6-9,11-13H2,1H3

SCYWWIINNKLBEF-UHFFFAOYSA-N

FC(C12CC(C1)(C2)C(N2CCN(CC2)C(=O)OCC)C=2C=NC=CC2)F

http://molview.org/?q=FC(C12CC(C1)(C2)C(N2CCN(CC2)C(=O)OCC)C=2C=NC=CC2)F

MFernflower commented 5 years ago

@edwintse @fantasy121 do we have anymore BCP-OH to oxidize to aldehyde?

fantasy121 commented 5 years ago

@MFernflower I think @edwintse would be able to better answer this question as I am unfamiliar with this synthesis route.