Open Meeting for School/University - 26 April 2023

[kym834]

Time: 12 noon (UK) 26 April 2023 Location: Zoom - https://ucl.zoom.us/j/99789829423 Chair: Matt or Kymberley Minute taker: Any takers?

Attendees:

Apologies: Alice (@alintheopen)

Agenda

1. Synthesis updates from:

   • Whitgift School
   • Sevenoaks School
   • University of York
   • Barker College
   • The University of Sydney

2. Update on series 2 SAR by Kymberley

3. Planning future compounds for synthesis

   • The University of Sydney

4. AOB

[PaulMcKeatingSevenoaks]

Our slide for today's meeting.

mycetos mtg 260423.pptx

[kym834]

Thanks @PaulMcKeatingSevenoaks!

Barker College's slides for the meeting: Mycetoma meeting update 26 April 2023.pptx

Kymberley's (@kym834) slides for the meeting: 20230426 MycetOS Meeting Slides.pptx

[KlementineJBS]

Breaking Good's slides for the meeting (University of Sydney):

High school workshop targets.pptx

[kym834]

Meeting minutes

1. Synthesis updates from:
   • Whitgift School: Finished making the 4-nitro molecule (will update MYOS number soon). Planning for the next one using 2-amino-5-methyl pyridine.
   • Sevenoaks School: Students draw in by the open science idea. Made something and will purify soon and send to UCL to see what it is. Asked about value to the project of having students working on the project with such a slow start to each round of synthesis. Considering changing how the project is done to give students more focussed time.
   • [ ] @kym834 to look into other cyclohexane based analogues for Sevenoaks to make in the next round.
   • University of York: Slides here. Also looked at bromo and nitrile substituents along with other 8 compounds and got some XRD for them! Still to be purified before sending on to Wendy/Mat for biological testing. Need to let @JuliaSarju know how and where to send samples. Students bought into community led element of the project. NMR and XRD files to be shared. Considering have 4 students work on this throughout the year next year.
   • Barker College: Have synthesised 1, on the last step of the other. Will send to USyd for analysis once made both.
   • [ ] @kym834 to get a link to the labnote books and add to Wiki as a data source
   • The University of Sydney: 18 compounds were synthesised and tested last year, 2 still to be sent.
2. Update on series 2 SAR by Kymberley
   • See slides for key SAR conclusions and suggestions for next steps.
   • Suggestions to expand through Suzuki coupling and nitro reductions.
3. Planning future compounds for synthesis
   • The University of Sydney: High school students coming in this year to make compounds. See slides for the compounds they are planning to make.
   • Erika (sorry don't know handle) and Mike have also been looking at possible compounds to make with master's students. Can you please share the slide you presented?
4. AOB
   • Whitgift has 3 more students who will continue on with chemistry - yay!
   • Mat asked for ideas for keeping track of suggested compounds - keen to have a new worksheet in the master data workbook for Series 2 - suggestions. Pros is that it can then be opened in Data Warrior and visualised.
   • [ ] @mattodd to bring up in the next MycetOS monthly meeting

[bebi78]

@kym834 @fantasy121 was investigating Suzuki and Buchwald for the fenarimols. Maybe he can share chemicals and experiences.

[kym834]

Thank @bebi78. That would be great! Hoping @fantasy121 experiences would give us an idea on feasibility for the high schools doing these reactions.

[mattodd]

For completeness, @JuliaSarju progress slide presented at the meeting

(Interim) Results Miniproject York 2023.pptx