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OpenSourceMycetoma / Series-2-Aminothiazoles

Series 2
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Aminothiazole analogues synthesized by Whitgift school 2024 #27

Open eloizidou opened 1 week ago

eloizidou commented 1 week ago

MYOS432 analysed by NMR and LCMS on March 2024 when students and teachers visited UCL School of Pharmacy. MYOS432 J+H.pdf JW+SC.pdf KSY+RC.pdf Q+Y.pdf Sam.pdf Summary of NMR plots.docx

MYOS605 analysed by NMR and LCMS on June 2024 during the second visit of students from Whitgift school at UCL School of Pharmacy. In vivo activity: percentage growth of M.mycetomatis at 100μΜ: 180.2 ± 42.2 and 25μΜ: 153.1 ± 100.7 MYOS605

AB+ZI.pdf AS+PO.pdf JW+BV.pdf KSY+RC.pdf Mark + Harry.pdf Q+Y.pdf whitgift240619_AB_ZI1.pdf whitgift240619_AB_ZI2.pdf whitgift240619_AS_PO_1.pdf whitgift240619_AS_PO_2.pdf whitgift240619_harry1.pdf whitgift240619_harry2.pdf whitgift240619_JW_BV_1.pdf whitgift240619_JW_BV_2.pdf whitgift240619_KSY_RC_1.pdf whitgift240619_KSY_RC_2.pdf whitgift240619_Q_XI_1.pdf whitgift240619_Q_XI_2.pdf

eloizidou commented 1 week ago

The next molecule to be synthesized by Whitgift is:

Whitgift molecule 3

KlementineJBS commented 4 days ago

Interesting that MYOS605 had such poor in vitro activity despite having the pyridine rings on both sides! I've updated the Wiki with these results and Whitgift's new target.

eloizidou commented 4 days ago

@Klementine @.***> yes I agree. It may be good to send the MYOS605 Whitgift sample to tested, the reported activity was from the same molecule synthesized in the past.

Erika Loizidou, PhD, FRSC, SFHEA Lecturer (Teaching) Drug Discovery Department of Pharmaceutical and Bio Chemistry Room B06 UCL School of Pharmacy 29-39 Brunswick Square London, WC1N 1AX, UK

From: Klementine Burrell-Sander @.> Sent: Thursday, June 27, 2024 5:32 AM To: OpenSourceMycetoma/Series-2-Aminothiazoles @.> Cc: Loizidou, Erika @.>; Assign @.> Subject: Re: [OpenSourceMycetoma/Series-2-Aminothiazoles] Aminothiazole analogues synthesized by Whitgift school 2024 (Issue #27)

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Interesting that MYOS605 had such poor in vitro activity despite having the pyridine rings on both sides! I've updated the Wiki with these results and Whitgift's new target.

— Reply to this email directly, view it on GitHubhttps://github.com/OpenSourceMycetoma/Series-2-Aminothiazoles/issues/27#issuecomment-2193673565, or unsubscribehttps://github.com/notifications/unsubscribe-auth/BC3PBSC2A6ZXRBDEKQFJCQ3ZJOIVFAVCNFSM6AAAAABJVO7JXKVHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMZDCOJTGY3TGNJWGU. You are receiving this because you were assigned.Message ID: @.***>