OpenSourceMycetoma / Series-2-Aminothiazoles

Series 2
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Requesting aminothiazole analogues from tuberculosis research group #28

Open KlementineJBS opened 1 month ago

KlementineJBS commented 1 month ago

Hey all,

there's a research group in Italy that has explored 2-aminothiazoles as anti-tubercular agents since 2012 and has made many analogues, including lots that we are yet to screen. I'd like to reach out and ask if they'd be interested in sharing some compounds to be tested against eumycetoma - do we have any particular protocol on how to do this? I'm particularly thinking about how to explain the project in terms of attribution/credit for their work.

I'm also keen for any suggestions people have on WHAT compounds we'd be interested in requesting! I'd definitely like to test some compounds made with amide or other linkers as well as compounds with an oxazole core but beyond that I'm not entirely certain what route to take.

Their most recent paper is very much focused on a specific compound but earlier work has a broader range of variations.

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2014: https://doi.org/10.1016/j.ejmech.2013.11.007

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2020: https://pubs.acs.org/doi/10.1021/acsmedchemlett.0c00173

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2023: https://pubmed.ncbi.nlm.nih.gov/36399878/

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KlementineJBS commented 1 month ago

I'd like to reach out soon, ideally this week - does anyone have suggestions? @mattodd @eloizidou @P-Rayner