OpenSourceMycetoma / Series-6-Ketoximes

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Wiki fixes and additions #4

Open mattodd opened 2 years ago

mattodd commented 2 years ago

Some fixes and additions needed for the wiki.

1) We need a custom sidebar so that the wiki looks like the others, e.g. for Series 1. Then remove the index from the left hand page of the existing wiki.

2) On the discovery of Series 6 page, remove all the fenarimol structures shown there, since those belong in the Series 1 wiki, and instead link to that screen (wherever it is in Series 1). Highlight that in that screen, three ketoximes were tested - the ones shown - and clarify which is pyrifenox.

3) In the SAR page, add in something about the discovery of pyrifenox that includes this 1986 mention and this 1991 abstract for completeness (though the story around that discovery seems a little murky). Also digest and summarise what is known about existing pyrifenox analogues, e.g. here.

4) This thesis definitely needs linking somewhere, since it covers the separation of E/Z isomers and the synthesis of some pyrifenox analogs. We need to ensure we have digested the contents, and we should be in touch with the group to see if we can secure some of the compounds. I've uploaded it here.

5) Link to relevant patents such as this and this

6) Check we've linked to other relevant papers such as this and this

7) References 451-462 in 10.1023/A:1026181918567 might also be worth checking.

This issue can be closed when the above is incorporated into the wiki. On an ongoing basis, we also need to keep an eye on the literature surrounding these reports, and there's a neat new tool that can help visualise that landscape to ensure we've covered it. This obviously need to be in parallel to manual searching with Web of Science and Google Scholar for any papers that cite the above reports.