Scoring for non-additive models that aren't dominant/recessive

PGScatalog / pgsc_calc

The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation

https://pgsc-calc.readthedocs.io/en/latest/

Apache License 2.0

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Scoring for non-additive models that aren't dominant/recessive #314

Open smlmbrt opened 4 months ago

smlmbrt commented 4 months ago

Need to implement a method to calculate PGS that only have the dosage_#_weight-type columns in the schema.

Discussed in https://github.com/PGScatalog/pgsc_calc/discussions/313

^{Originally posted by **DarioS** June 14, 2024} PGS Catalog has incorporated non-additive models from [PGP000546](http://pgscatalog.org/publication/PGP000546/) two days ago. Can PGSC Calc use such models correctly? ![image](https://github.com/PGScatalog/pgsc_calc/assets/631218/f81c308a-da07-4bc0-8766-aa6167c526fb)

smlmbrt commented 2 months ago

PGScatalog/pygscatalog#44 shows that these types of scores currently cause an error within pygscatalog. Will fix so they don't cause the whole calculator to crash, but it will probably take a lot longer to implement dosage specific scoring.