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Pathogen-Host Interaction Phenotype Ontology
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Need to develop terms for host granulocytes killing Af fungal hyphae #426

Open CuzickA opened 11 months ago

CuzickA commented 11 months ago

For https://github.com/PHI-base/curation/issues/108

We currently have PHIPO terms for pathogen killing host at the cell and organism level. We don't have any terms for the host killing the pathogen.

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Suggestions 'pathogen organism viability with host phenotype' as a sibling term to 'host organism viability with pathogen phenotype' child term 'death of pathogen organism with host'

I think this needs to be at the pathogen organism level as the expt shows Aspergillus fumigatus fungal hyphae (multicellular) being killed by human granulocytes (Polymorphonuclear neutrophils).

I'm not sure whether more detail needs to be capture in the term about host defense response of the granulocytes. maybe 'host defense-induced granulocyte killing of pathogen present'

We are planning to curate more Aspergillus fumigatus literature so I think it would be useful to get these PHIPO terms in place for some of the host-defence responses to human/animal pathogens.

To follow up with @ValWood in the New Year :-)