NTR: Gonadotropin

[nataled]

Can this be added to PRO? http://en.wikipedia.org/wiki/Gonadotropin

Reported by: drseb

[nataled]

• assigned_to: Cecilia Arighi
• Group: -->

Original comment by: nataled

[nataled]

Dear Sebastian, I was assigned to review your term request. I need further clarification from you. Gonadotropins are really complexes (heterodimers of an alpha and a beta subunits). Are you interested in the generic complexes or individual chains? Thanks for the clarification Regards, Cecilia

Original comment by: carighi

[nataled]

Dear Sebastian,

I was assigned to review your term request. I need further clarification from you. Gonadotropins are really complexes (heterdimers of an alpha and a beta subunits). Are you interested in the generic complexes or individual chains?

Thanks for the clarification

Regards, Cecilia

From: Darren Natale [mailto:darren_natale@users.sf.net] Sent: Monday, April 13, 2015 10:17 AM To: [pro-obo:term-requests] Subject: [pro-obo:term-requests] #96 NTR: Gonadotropin

• assigned_to: Cecilia Arighi

• Group: -->

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[term-requests:#96] http://sourceforge.net/p/pro-obo/term-requests/96 NTR: Gonadotropin

Status: open Group: Created: Mon Apr 13, 2015 01:30 PM UTC by Sebastian Köhler Last Updated: Mon Apr 13, 2015 01:30 PM UTC Owner: Cecilia Arighi

Can this be added to PRO? http://en.wikipedia.org/wiki/Gonadotropin

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Original comment by: carighi

[nataled]

Thank you very much for your prompt reply. We would need this class for logical definitions in HPO. The HPO classes we would like to logically define are 'Gonadotropin excess' and 'Gonadotropin deficiency'. These are textually defined as: "Overproduction of gonadotropins (FSH, LH) by the anterior pituitary gland." and "A reduced ability to secrete gonadotropins, which are protein hormones secreted by gonadotrope cells of the anterior pituitary gland, including the hormones follitropin (FSH) and luteinizing hormone (LH)." , respectively.

I hope this helps. Let me know if you need more information.

Best, Sebastian

Original comment by: drseb

[nataled]

Dear Sebastian,

I have an additional question for you. But first want to give you some clarification. Since gonadotropin would be considered a complex, both GO and PRO are the ontologies to host it. GO deals with complexes that are conserved in many species and terms are made generic (non-species specific). Currently GO does not have Gonadotropin, but it does have the term GO:0016914 follicle-stimulating hormone complex, which should be a child of gonadotropin. PRO, on the other hand, would make the corresponding species-specific complexes. For example, if you are interested in human gonadotropin term then PRO would be the ontology to host it.

So the question is: Would the term gonadotropin (human) be OK for your purpose, or do you need the species agnostic term (which should be requested to GO)?

Thanks in advance,

Regards,

cecilia

From: "Sebastian Köhler" [mailto:koehlers@users.sf.net] Sent: Tuesday, April 14, 2015 4:21 AM To: [pro-obo:term-requests] Subject: [pro-obo:term-requests] #96 NTR: Gonadotropin

Thank you very much for your prompt reply. We would need this class for logical definitions in HPO. The HPO classes we would like to logically define are 'Gonadotropin excess' and 'Gonadotropin deficiency'. These are textually defined as: "Overproduction of gonadotropins (FSH, LH) by the anterior pituitary gland." and "A reduced ability to secrete gonadotropins, which are protein hormones secreted by gonadotrope cells of the anterior pituitary gland, including the hormones follitropin (FSH) and luteinizing hormone (LH)." , respectively.

I hope this helps. Let me know if you need more information.

Best, Sebastian

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[term-requests:#96] http://sourceforge.net/p/pro-obo/term-requests/96 NTR: Gonadotropin

Status: open Group: Created: Mon Apr 13, 2015 01:30 PM UTC by Sebastian Köhler Last Updated: Mon Apr 13, 2015 03:09 PM UTC Owner: Cecilia Arighi

Can this be added to PRO? http://en.wikipedia.org/wiki/Gonadotropin

---

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Original comment by: carighi

[nataled]

Thank you very much for your input. Let me speak with some GO- and Phenotype-people and I will get back to you ASAP!

Thanks

Original comment by: drseb

[nataled]

OK No problem

Ceci

From: "Sebastian Köhler" [mailto:koehlers@users.sf.net] Sent: Tuesday, April 14, 2015 11:16 AM To: [pro-obo:term-requests] Subject: [pro-obo:term-requests] #96 NTR: Gonadotropin

Thank you very much for your input. Let me speak with some GO- and Phenotype-people and I will get back to you ASAP!

Thanks

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[term-requests:#96] http://sourceforge.net/p/pro-obo/term-requests/96 NTR: Gonadotropin

Status: open Group: Created: Mon Apr 13, 2015 01:30 PM UTC by Sebastian Köhler Last Updated: Tue Apr 14, 2015 08:20 AM UTC Owner: Cecilia Arighi

Can this be added to PRO? http://en.wikipedia.org/wiki/Gonadotropin

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Original comment by: carighi

[nataled]

Sorry for the delay. The GO people will create relatively species-agnostic class which will do the job for the mouse/human/etc people.

Thank you very much!

Original comment by: drseb

[nataled]

See https://sourceforge.net/p/geneontology/ontology-requests/11675/

Original comment by: drseb

[nataled]

• status: open --> closed

Original comment by: nataled