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Term issue: mid1 phosphorylated form #225

Closed ValWood closed 3 years ago

ValWood commented 3 years ago

mid1 P78953 modified residue S110, S127, S218, S227, S329, S432, S452, S464, S531 added by sid2 during mitotic M phase

(Sid2 phosphorylates Mid1 to drive its removal from the cortex at CR constriction onset. ) PMID:30853434

Also a unphosphorylated form for these residues

nataled commented 3 years ago

Hi Val, Here are your terms:

Phosphorylated: PR:000050492 mid1/Phos(S110, S127, S218, S227, S329, S432, S452, S464, S531) Unphosphorylated: PR:000050493 mid1/UnPhos(S110, S127, S218, S227, S329, S432, S452, S464, S531)

[Term] id: PR:000050492 name: division mal foutue 1 protein phosphorylated 1 (Schizosaccharomyces pombe) def: "A division mal foutue 1 protein (Schizosaccharomyces pombe) that has been phosphorylated at the positions equivalent to Ser-110, Ser-127, Ser-218, Ser-227, Ser-329, Ser-432, Ser-452, Ser-464, and Ser-531 of the amino acid sequence represented by UniProtKB:P78953. Example: UniProtKB:P78953, Ser-110/Ser-127/Ser-218/Ser-227/Ser-329/Ser-432/Ser-452/Ser-464/Ser-531, MOD:00046." [PRO:DAN, PomBase:VW, PMID:30853434] comment: Category=organism-modification. Requested by=PomBase. Kinase=("sid2"; PR:000050490; Ser-110/Ser-127/Ser-218/Ser-227/Ser-329/Ser-432/Ser-452/Ser-464/Ser-531). synonym: "Spom-mid1/Phos:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P78953, Ser-110/Ser-127/Ser-218/Ser-227/Ser-329/Ser-432/Ser-452/Ser-464/Ser-531, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:000050491 ! division mal foutue 1 protein (Schizosaccharomyces pombe) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe

[Term] id: PR:000050493 name: division mal foutue 1 protein phosphorylated 1 (Schizosaccharomyces pombe) def: "A division mal foutue 1 protein (Schizosaccharomyces pombe) that has not been phosphorylated at the positions equivalent to Ser-110, Ser-127, Ser-218, Ser-227, Ser-329, Ser-432, Ser-452, Ser-464, and Ser-531 of the amino acid sequence represented by UniProtKB:P78953. Example: UniProtKB:P78953, Ser-110/Ser-127/Ser-218/Ser-227/Ser-329/Ser-432/Ser-452/Ser-464/Ser-531, PR:000026291." [PRO:DAN, PomBase:VW, PMID:30853434] comment: Category=organism-modification. Requested by=PomBase. synonym: "Spom-mid1/Phos:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P78953, Ser-110/Ser-127/Ser-218/Ser-227/Ser-329/Ser-432/Ser-452/Ser-464/Ser-531, PR:000026291" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:000050491 ! division mal foutue 1 protein (Schizosaccharomyces pombe) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe

ValWood commented 3 years ago

Hi Darren, Are the names automated from Uniprot. I was confused when I saw "division mal foutue 1" because I have never seen Mid1 called this. I traced to a very early allele description. I'll ask UniProt to update the protein name today to "~allinin~ anillin-related medial ring protein". Will this change filter through to PRO? v

ValWood commented 3 years ago

Also PR:000050493 should unphosporylated.

nataled commented 3 years ago

Thanks for catching the typo. I had caught it as well, but only after I posted my reply. As for the name, consider it done. The UniProt name did look odd to me. I mean, for English. Turns out it is French, whose Google translation is...interesting. In any case, I've already made the change in PRO, and will upload after I attend to your next request.

ValWood commented 3 years ago

Yeah on the old paper and was Swiss-French, and the Uniprot Fungal curators are too so they probably liked it ;)