PathwayCommons / cpath2

Biological pathway data integration and access platform (Pathway Commons)
http://www.pathwaycommons.org/pc2/
MIT License
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Extended SIF PubMed IDs column: Source(s) #314

Closed jvwong closed 1 year ago

jvwong commented 2 years ago

The data in EXTENDED_BINARY_SIF format, served from (beta) SIFGraph service contains a column for PubMed IDs (section 1, column 5).

For example, the neighbourhood of TLN1 outputs:

SIRT7   interacts-with  TLN1    BioGRID 22586326        http://pathwaycommons.org/pc13/MolecularInteraction_37c9957e-9ead-4e5f-96d0-670284d6d247___null__86182_
...
ELF1    controls-expression-of  TLN1    MSigDB          http://pathwaycommons.org/pc13/TemplateReactionRegulation_d7aa58d38362a28444d8151192413cee;http://pathwaycommons.org/pc13/TemplateReaction_b4d560bcfc2e59fef106f19a7dada50c
KANK1   interacts-with  TLN1    Biofactoid      Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.  http://pathwaycommons.org/pc13/MolecularInteraction_635a5bb6bc9090144a4d3fd44ce76095
 ...

Looks like in a lot of cases the PubMed IDs are drawn from BioPAX bp:Evidence attached to the interaction. I wonder if:

  1. Would a bp:PublicationXref directly attached to an interaction end up in the extended SIF? Or is it being exclusively drawn from bp:Evidence?
  2. If #1 is true generally(not only Evidence): Is it justified to attach a Biofactoid entry's PubMed ID (the one already attached to the bp:Pathway) to the constituent interactions as a bp:PublicationXref in BioPAX? (I guess we won't really have anything approaching bp:Evidence from Biofactoid)

The real reason I ask is because the app-ui interaction app will retrieve the PMID-associated paper info, but this currently won't happen for Biofactoid-derived data:

Screen Shot 2022-06-29 at 2 31 07 PM
IgorRodchenkov commented 1 year ago

@jvwong , I dived into our code and found the following:

Hope it helps. Ask @ozgunbabur too.